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Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.
Bracaglia C, de Graaf K, Pires Marafon D, Guilhot F, Ferlin W, Prencipe G, Caiello I, Davì S, Schulert G, Ravelli A, Grom AA, de Min C, De Benedetti F. Bracaglia C, et al. Among authors: guilhot f. Ann Rheum Dis. 2017 Jan;76(1):166-172. doi: 10.1136/annrheumdis-2015-209020. Epub 2016 Jun 13. Ann Rheum Dis. 2017. PMID: 27296321
Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity.
Lissilaa R, Buatois V, Magistrelli G, Williams AS, Jones GW, Herren S, Shang L, Malinge P, Guilhot F, Chatel L, Hatterer E, Jones SA, Kosco-Vilbois MH, Ferlin WG. Lissilaa R, et al. Among authors: guilhot f. J Immunol. 2010 Nov 1;185(9):5512-21. doi: 10.4049/jimmunol.1002015. Epub 2010 Sep 24. J Immunol. 2010. PMID: 20870936
Novel Insights into Interleukin 6 (IL-6) Cis- and Trans-signaling Pathways by Differentially Manipulating the Assembly of the IL-6 Signaling Complex.
Lacroix M, Rousseau F, Guilhot F, Malinge P, Magistrelli G, Herren S, Jones SA, Jones GW, Scheller J, Lissilaa R, Kosco-Vilbois M, Johnson Z, Buatois V, Ferlin W. Lacroix M, et al. Among authors: guilhot f. J Biol Chem. 2015 Nov 6;290(45):26943-26953. doi: 10.1074/jbc.M115.682138. Epub 2015 Sep 11. J Biol Chem. 2015. PMID: 26363066 Free PMC article.
NI-0801, an anti-chemokine (C-X-C motif) ligand 10 antibody, in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid.
de Graaf KL, Lapeyre G, Guilhot F, Ferlin W, Curbishley SM, Carbone M, Richardson P, Moreea S, McCune CA, Ryder SD, Chapman RW, Floreani A, Jones DE, de Min C, Adams DH, Invernizzi P. de Graaf KL, et al. Among authors: guilhot f. Hepatol Commun. 2018 Mar 23;2(5):492-503. doi: 10.1002/hep4.1170. eCollection 2018 May. Hepatol Commun. 2018. PMID: 29761166 Free PMC article.
Rapid, simple and high yield production of recombinant proteins in mammalian cells using a versatile episomal system.
Magistrelli G, Malinge P, Lissilaa R, Fagète S, Guilhot F, Moine V, Buatois V, Delneste Y, Kellenberger S, Gueneau F, Ravn U, Kosco-Vilbois M, Fischer N. Magistrelli G, et al. Among authors: guilhot f. Protein Expr Purif. 2010 Aug;72(2):209-16. doi: 10.1016/j.pep.2010.04.007. Epub 2010 Apr 24. Protein Expr Purif. 2010. PMID: 20399863 Free article.
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.
Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, Lissilaa R, Ferlin WG, Grötzinger J, Jones SA, Rose-John S, Scheller J. Garbers C, et al. Among authors: guilhot f. J Biol Chem. 2011 Dec 16;286(50):42959-70. doi: 10.1074/jbc.M111.295758. Epub 2011 Oct 11. J Biol Chem. 2011. PMID: 21990364 Free PMC article.
335 results