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Long-term administration of the mitochondria-targeted antioxidant mitoquinone mesylate fails to attenuate age-related oxidative damage or rescue the loss of muscle mass and function associated with aging of skeletal muscle.
Sakellariou GK, Pearson T, Lightfoot AP, Nye GA, Wells N, Giakoumaki II, Griffiths RD, McArdle A, Jackson MJ. Sakellariou GK, et al. FASEB J. 2016 Nov;30(11):3771-3785. doi: 10.1096/fj.201600450R. Epub 2016 Aug 22. FASEB J. 2016. PMID: 27550965 Free PMC article.
Studies of mitochondrial and nonmitochondrial sources implicate nicotinamide adenine dinucleotide phosphate oxidase(s) in the increased skeletal muscle superoxide generation that occurs during contractile activity.
Sakellariou GK, Vasilaki A, Palomero J, Kayani A, Zibrik L, McArdle A, Jackson MJ. Sakellariou GK, et al. Antioxid Redox Signal. 2013 Feb 20;18(6):603-21. doi: 10.1089/ars.2012.4623. Epub 2012 Dec 6. Antioxid Redox Signal. 2013. PMID: 23050834 Free PMC article.
Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype.
Sataranatarajan K, Qaisar R, Davis C, Sakellariou GK, Vasilaki A, Zhang Y, Liu Y, Bhaskaran S, McArdle A, Jackson M, Brooks SV, Richardson A, Van Remmen H. Sataranatarajan K, et al. Among authors: sakellariou gk. Redox Biol. 2015 Aug;5:140-148. doi: 10.1016/j.redox.2015.04.005. Epub 2015 Apr 15. Redox Biol. 2015. PMID: 25917273 Free PMC article.
SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes.
Lightfoot AP, Sakellariou GK, Nye GA, McArdle F, Jackson MJ, Griffiths RD, McArdle A. Lightfoot AP, et al. Among authors: sakellariou gk. Redox Biol. 2015 Dec;6:253-259. doi: 10.1016/j.redox.2015.08.007. Epub 2015 Aug 10. Redox Biol. 2015. PMID: 26291279 Free PMC article.
26 results