Singer T - Search Results

1

Culture and Drug Profiling of Patient Derived Malignant Pleural Effusions for Personalized Cancer Medicine.

Ruiz C, Kustermann S, Pietilae E, Vlajnic T, Baschiera B, Arabi L, Lorber T, Oeggerli M, Savic S, Obermann E, Singer T, Rothschild SI, Zippelius A, Roth AB, Bubendorf L. Ruiz C, et al. Among authors: singer t. PLoS One. 2016 Aug 22;11(8):e0160807. doi: 10.1371/journal.pone.0160807. eCollection 2016. PLoS One. 2016. PMID: 27548442 Free PMC article.

2

The application of 3D cell models to support drug safety assessment: opportunities & challenges.

Roth A, Singer T. Roth A, et al. Among authors: singer t. Adv Drug Deliv Rev. 2014 Apr;69-70:179-89. doi: 10.1016/j.addr.2013.12.005. Epub 2013 Dec 27. Adv Drug Deliv Rev. 2014. PMID: 24378580 Review.

3

Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro.

Nguyen DG, Funk J, Robbins JB, Crogan-Grundy C, Presnell SC, Singer T, Roth AB. Nguyen DG, et al. Among authors: singer t. PLoS One. 2016 Jul 7;11(7):e0158674. doi: 10.1371/journal.pone.0158674. eCollection 2016. PLoS One. 2016. PMID: 27387377 Free PMC article.

4

A real-time impedance-based screening assay for drug-induced vascular leakage.

Kustermann S, Manigold T, Ploix C, Skubatz M, Heckel T, Hinton H, Weiser T, Singer T, Suter L, Roth A. Kustermann S, et al. Among authors: singer t. Toxicol Sci. 2014 Apr;138(2):333-43. doi: 10.1093/toxsci/kft336. Epub 2014 Jan 2. Toxicol Sci. 2014. PMID: 24385420

5

Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs.

Sewing S, Boess F, Moisan A, Bertinetti-Lapatki C, Minz T, Hedtjaern M, Tessier Y, Schuler F, Singer T, Roth AB. Sewing S, et al. Among authors: singer t. PLoS One. 2016 Jul 21;11(7):e0159431. doi: 10.1371/journal.pone.0159431. eCollection 2016. PLoS One. 2016. PMID: 27442522 Free PMC article.

6

A label-free, impedance-based real time assay to identify drug-induced toxicities and differentiate cytostatic from cytotoxic effects.

Kustermann S, Boess F, Buness A, Schmitz M, Watzele M, Weiser T, Singer T, Suter L, Roth A. Kustermann S, et al. Among authors: singer t. Toxicol In Vitro. 2013 Aug;27(5):1589-95. doi: 10.1016/j.tiv.2012.08.019. Epub 2012 Aug 28. Toxicol In Vitro. 2013. PMID: 22954529

7

Use of early phenotypic in vivo markers to assess human relevance of an unusual rodent non-genotoxic carcinogen in vitro.

Boess F, Lenz B, Funk J, Niederhauser U, Bassett S, Zhang JD, Singer T, Roth AB. Boess F, et al. Among authors: singer t. Toxicology. 2017 Mar 15;379:48-61. doi: 10.1016/j.tox.2017.01.018. Epub 2017 Feb 5. Toxicology. 2017. PMID: 28174063

8

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity.

Kostadinova R, Boess F, Applegate D, Suter L, Weiser T, Singer T, Naughton B, Roth A. Kostadinova R, et al. Among authors: singer t. Toxicol Appl Pharmacol. 2013 Apr 1;268(1):1-16. doi: 10.1016/j.taap.2013.01.012. Epub 2013 Jan 23. Toxicol Appl Pharmacol. 2013. PMID: 23352505

9

Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia.

Sewing S, Roth AB, Winter M, Dieckmann A, Bertinetti-Lapatki C, Tessier Y, McGinnis C, Huber S, Koller E, Ploix C, Reed JC, Singer T, Rothfuss A. Sewing S, et al. Among authors: singer t. PLoS One. 2017 Nov 6;12(11):e0187574. doi: 10.1371/journal.pone.0187574. eCollection 2017. PLoS One. 2017. PMID: 29107969 Free PMC article.

10

Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling.

Moisan A, Gubler M, Zhang JD, Tessier Y, Dumong Erichsen K, Sewing S, Gérard R, Avignon B, Huber S, Benmansour F, Chen X, Villaseñor R, Braendli-Baiocco A, Festag M, Maunz A, Singer T, Schuler F, Roth AB. Moisan A, et al. Among authors: singer t. Mol Ther Nucleic Acids. 2017 Mar 17;6:89-105. doi: 10.1016/j.omtn.2016.11.006. Epub 2016 Dec 10. Mol Ther Nucleic Acids. 2017. PMID: 28325303 Free PMC article.

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