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Metabolism and excretion of 1-hydroxymethylpyrene, the proximate metabolite of the carcinogen 1-methylpyrene, in rats.
Toxicology. 2016 Jul 29;366-367:43-52. doi: 10.1016/j.tox.2016.08.006. Epub 2016 Aug 5.
Toxicology. 2016.
PMID: 27501763
The carcinogen 1-methylpyrene forms benzylic DNA adducts in mouse and rat tissues in vivo via a reactive sulphuric acid ester.
Bendadani C, Meinl W, Monien BH, Dobbernack G, Glatt H.
Bendadani C, et al.
Arch Toxicol. 2014 Mar;88(3):815-21. doi: 10.1007/s00204-013-1182-6. Epub 2013 Dec 13.
Arch Toxicol. 2014.
PMID: 24337722
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Determination of sulfotransferase forms involved in the metabolic activation of the genotoxicant 1-hydroxymethylpyrene using bacterially expressed enzymes and genetically modified mouse models.
Bendadani C, Meinl W, Monien B, Dobbernack G, Florian S, Engst W, Nolden T, Himmelbauer H, Glatt H.
Bendadani C, et al.
Chem Res Toxicol. 2014 Jun 16;27(6):1060-9. doi: 10.1021/tx500129g. Epub 2014 May 22.
Chem Res Toxicol. 2014.
PMID: 24802129
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