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ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle.
Nordgaard C, Vind AC, Stonadge A, Kjøbsted R, Snieckute G, Antas P, Blasius M, Reinert MS, Del Val AM, Bekker-Jensen DB, Haahr P, Miroshnikova YA, Mazouzi A, Falk S, Perrier-Groult E, Tiedje C, Li X, Jakobsen JR, Jørgensen NO, Wojtaszewski JF, Mallein-Gerin F, Andersen JL, Pennisi CP, Clemmensen C, Kassem M, Jafari A, Brummelkamp T, Li VS, Wickström SA, Olsen JV, Blanco G, Bekker-Jensen S. Nordgaard C, et al. Among authors: blanco g. EMBO J. 2022 Sep 1;41(17):e111650. doi: 10.15252/embj.2022111650. Epub 2022 Jul 28. EMBO J. 2022. PMID: 35899396 Free PMC article.
Recessive mutations in the kinase ZAK cause a congenital myopathy with fibre type disproportion.
Vasli N, Harris E, Karamchandani J, Bareke E, Majewski J, Romero NB, Stojkovic T, Barresi R, Tasfaout H, Charlton R, Malfatti E, Bohm J, Marini-Bettolo C, Choquet K, Dicaire MJ, Shao YH, Topf A, O'Ferrall E, Eymard B, Straub V, Blanco G, Lochmüller H, Brais B, Laporte J, Tétreault M. Vasli N, et al. Among authors: blanco g. Brain. 2017 Jan;140(1):37-48. doi: 10.1093/brain/aww257. Epub 2016 Nov 5. Brain. 2017. PMID: 27816943 Free PMC article.
IGFN1_v1 is required for myoblast fusion and differentiation.
Li X, Baker J, Cracknell T, Haynes AR, Blanco G. Li X, et al. Among authors: blanco g. PLoS One. 2017 Jun 30;12(6):e0180217. doi: 10.1371/journal.pone.0180217. eCollection 2017. PLoS One. 2017. PMID: 28665998 Free PMC article.
636 results