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Identification of a new potential mechanism responsible for severe bleeding in myeloma: immunoglobulins bind the heparin binding domain of antithrombin activating this endogenous anticoagulant.
Martínez-Martínez I, González-Porras JR, Cebeira MJ, de Arriba F, Espín S, Bohdan N, Corrales FJ, Corral J, Vicente V. Martínez-Martínez I, et al. Among authors: de arriba f. Haematologica. 2016 Oct;101(10):e423-e426. doi: 10.3324/haematol.2016.144873. Epub 2016 Jun 16. Haematologica. 2016. PMID: 27479819 Free PMC article. No abstract available.
Inhibition of proteasome by bortezomib causes intracellular aggregation of hepatic serpins and increases the latent circulating form of antithrombin.
Hernández-Espinosa D, Miñano A, Martínez C, Ordoñez A, Pérez-Ceballos E, de Arriba F, Mota RA, Ferrer F, González M, Vicente V, Corral J. Hernández-Espinosa D, et al. Among authors: de arriba f. Lab Invest. 2008 Mar;88(3):306-17. doi: 10.1038/labinvest.3700717. Epub 2008 Jan 14. Lab Invest. 2008. PMID: 18195690 Free article. Clinical Trial.
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