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Insight on Mutation-Induced Resistance from Molecular Dynamics Simulations of the Native and Mutated CSF-1R and KIT.
Da Silva Figueiredo Celestino Gomes P, Chauvot De Beauchêne I, Panel N, Lopez S, De Sepulveda P, Geraldo Pascutti P, Solary E, Tchertanov L. Da Silva Figueiredo Celestino Gomes P, et al. Among authors: de sepulveda p. PLoS One. 2016 Jul 28;11(7):e0160165. doi: 10.1371/journal.pone.0160165. eCollection 2016. PLoS One. 2016. PMID: 27467080 Free PMC article.
Characterization of S628N: a novel KIT mutation found in a metastatic melanoma.
Vita M, Tisserand JC, Chauvot de Beauchêne I, Panel N, Tchertanov L, Agopian J, Mescam-Mancini L, Fouet B, Fournier B, Dubreuil P, Bertucci F, De Sepulveda P. Vita M, et al. Among authors: de sepulveda p. JAMA Dermatol. 2014 Dec;150(12):1345-9. doi: 10.1001/jamadermatol.2014.1437. JAMA Dermatol. 2014. PMID: 25317746
FES kinase participates in KIT-ligand induced chemotaxis.
Voisset E, Lopez S, Chaix A, Vita M, George C, Dubreuil P, De Sepulveda P. Voisset E, et al. Among authors: de sepulveda p. Biochem Biophys Res Commun. 2010 Feb 26;393(1):174-8. doi: 10.1016/j.bbrc.2010.01.116. Epub 2010 Feb 1. Biochem Biophys Res Commun. 2010. PMID: 20117079
Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.
Hammam K, Saez-Ayala M, Rebuffet E, Gros L, Lopez S, Hajem B, Humbert M, Baudelet E, Audebert S, Betzi S, Lugari A, Combes S, Letard S, Casteran N, Mansfield C, Moussy A, De Sepulveda P, Morelli X, Dubreuil P. Hammam K, et al. Among authors: de sepulveda p. Nat Commun. 2017 Nov 10;8(1):1420. doi: 10.1038/s41467-017-01582-5. Nat Commun. 2017. PMID: 29127277 Free PMC article.
SRC-Family Kinases in Acute Myeloid Leukaemia and Mastocytosis.
Voisset E, Brenet F, Lopez S, de Sepulveda P. Voisset E, et al. Among authors: de sepulveda p. Cancers (Basel). 2020 Jul 21;12(7):1996. doi: 10.3390/cancers12071996. Cancers (Basel). 2020. PMID: 32708273 Free PMC article. Review.
KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570.
Chaix A, Arcangeli ML, Lopez S, Voisset E, Yang Y, Vita M, Letard S, Audebert S, Finetti P, Birnbaum D, Bertucci F, Aurrand-Lions M, Dubreuil P, De Sepulveda P. Chaix A, et al. Among authors: de sepulveda p. Oncogene. 2014 Feb 13;33(7):872-81. doi: 10.1038/onc.2013.12. Epub 2013 Feb 18. Oncogene. 2014. PMID: 23416972
Pediatric mastocytosis-associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations.
Yang Y, Létard S, Borge L, Chaix A, Hanssens K, Lopez S, Vita M, Finetti P, Birnbaum D, Bertucci F, Gomez S, de Sepulveda P, Dubreuil P. Yang Y, et al. Among authors: de sepulveda p. Blood. 2010 Aug 19;116(7):1114-23. doi: 10.1182/blood-2009-06-226027. Epub 2010 May 18. Blood. 2010. PMID: 20484085 Free article.
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