Wengel J - Search Results

1

Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic.

Lou C, Martos-Maldonado MC, Madsen CS, Thomsen RP, Midtgaard SR, Christensen NJ, Kjems J, Thulstrup PW, Wengel J, Jensen KJ. Lou C, et al. Among authors: wengel j. Nat Commun. 2016 Jul 28;7:12294. doi: 10.1038/ncomms12294. Nat Commun. 2016. PMID: 27464951 Free PMC article.

2

Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites.

Jakobsen MR, Haasnoot J, Wengel J, Berkhout B, Kjems J. Jakobsen MR, et al. Among authors: wengel j. Retrovirology. 2007 Apr 26;4:29. doi: 10.1186/1742-4690-4-29. Retrovirology. 2007. PMID: 17459171 Free PMC article.

3

Improved silencing properties using small internally segmented interfering RNAs.

Bramsen JB, Laursen MB, Damgaard CK, Lena SW, Babu BR, Wengel J, Kjems J. Bramsen JB, et al. Among authors: wengel j. Nucleic Acids Res. 2007;35(17):5886-97. doi: 10.1093/nar/gkm548. Epub 2007 Aug 28. Nucleic Acids Res. 2007. PMID: 17726057 Free PMC article.

4

Perylene attached to 2'-amino-LNA: synthesis, incorporation into oligonucleotides, and remarkable fluorescence properties in vitro and in cell culture.

Astakhova IV, Korshun VA, Jahn K, Kjems J, Wengel J. Astakhova IV, et al. Among authors: wengel j. Bioconjug Chem. 2008 Oct;19(10):1995-2007. doi: 10.1021/bc800202v. Epub 2008 Sep 5. Bioconjug Chem. 2008. PMID: 18771303

5

The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.

Gao S, Dagnaes-Hansen F, Nielsen EJ, Wengel J, Besenbacher F, Howard KA, Kjems J. Gao S, et al. Among authors: wengel j. Mol Ther. 2009 Jul;17(7):1225-33. doi: 10.1038/mt.2009.91. Epub 2009 Apr 28. Mol Ther. 2009. PMID: 19401674 Free PMC article.

6

Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration.

Glud SZ, Bramsen JB, Dagnaes-Hansen F, Wengel J, Howard KA, Nyengaard JR, Kjems J. Glud SZ, et al. Among authors: wengel j. Oligonucleotides. 2009 Jun;19(2):163-8. doi: 10.1089/oli.2008.0175. Oligonucleotides. 2009. PMID: 19441893

7

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.

Bramsen JB, Pakula MM, Hansen TB, Bus C, Langkjær N, Odadzic D, Smicius R, Wengel SL, Chattopadhyaya J, Engels JW, Herdewijn P, Wengel J, Kjems J. Bramsen JB, et al. Among authors: wengel j, wengel sl. Nucleic Acids Res. 2010 Sep;38(17):5761-73. doi: 10.1093/nar/gkq341. Epub 2010 May 7. Nucleic Acids Res. 2010. PMID: 20453030 Free PMC article.

8

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo.

Laursen MB, Pakula MM, Gao S, Fluiter K, Mook OR, Baas F, Langklaer N, Wengel SL, Wengel J, Kjems J, Bramsen JB. Laursen MB, et al. Among authors: wengel j, wengel sl. Mol Biosyst. 2010 May;6(5):862-70. doi: 10.1039/b918869j. Epub 2010 Feb 9. Mol Biosyst. 2010. PMID: 20567772

9

In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important.

Schyth BD, Bramsen JB, Pakula MM, Larashati S, Kjems J, Wengel J, Lorenzen N. Schyth BD, et al. Among authors: wengel j. Nucleic Acids Res. 2012 May;40(10):4653-65. doi: 10.1093/nar/gks033. Epub 2012 Jan 28. Nucleic Acids Res. 2012. PMID: 22287630 Free PMC article.

10

Peptide-LNA oligonucleotide conjugates.

Astakhova IK, Hansen LH, Vester B, Wengel J. Astakhova IK, et al. Among authors: wengel j. Org Biomol Chem. 2013 Jul 7;11(25):4240-9. doi: 10.1039/c3ob40786a. Org Biomol Chem. 2013. PMID: 23681061 Free article.

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