Shanahan CM - Search Results

1

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient.

Cobb AM, Larrieu D, Warren DT, Liu Y, Srivastava S, Smith AJO, Bowater RP, Jackson SP, Shanahan CM. Cobb AM, et al. Among authors: shanahan cm. Aging Cell. 2016 Dec;15(6):1039-1050. doi: 10.1111/acel.12506. Epub 2016 Jul 27. Aging Cell. 2016. PMID: 27464478 Free PMC article.

2

Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle.

Zhang Q, Ragnauth CD, Skepper JN, Worth NF, Warren DT, Roberts RG, Weissberg PL, Ellis JA, Shanahan CM. Zhang Q, et al. Among authors: shanahan cm. J Cell Sci. 2005 Feb 15;118(Pt 4):673-87. doi: 10.1242/jcs.01642. Epub 2005 Jan 25. J Cell Sci. 2005. PMID: 15671068

3

Nesprins: intracellular scaffolds that maintain cell architecture and coordinate cell function?

Warren DT, Zhang Q, Weissberg PL, Shanahan CM. Warren DT, et al. Among authors: shanahan cm. Expert Rev Mol Med. 2005 Jun 13;7(11):1-15. doi: 10.1017/S1462399405009294. Expert Rev Mol Med. 2005. PMID: 15953398 Review.

4

Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.

Zhang Q, Bethmann C, Worth NF, Davies JD, Wasner C, Feuer A, Ragnauth CD, Yi Q, Mellad JA, Warren DT, Wheeler MA, Ellis JA, Skepper JN, Vorgerd M, Schlotter-Weigel B, Weissberg PL, Roberts RG, Wehnert M, Shanahan CM. Zhang Q, et al. Among authors: shanahan cm. Hum Mol Genet. 2007 Dec 1;16(23):2816-33. doi: 10.1093/hmg/ddm238. Epub 2007 Aug 29. Hum Mol Genet. 2007. PMID: 17761684

5

Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation.

Warren DT, Tajsic T, Mellad JA, Searles R, Zhang Q, Shanahan CM. Warren DT, et al. Among authors: shanahan cm. J Biol Chem. 2010 Jan 8;285(2):1311-20. doi: 10.1074/jbc.M109.032557. Epub 2009 Oct 27. J Biol Chem. 2010. PMID: 19861416 Free PMC article.

6

Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging.

Ragnauth CD, Warren DT, Liu Y, McNair R, Tajsic T, Figg N, Shroff R, Skepper J, Shanahan CM. Ragnauth CD, et al. Among authors: shanahan cm. Circulation. 2010 May 25;121(20):2200-10. doi: 10.1161/CIRCULATIONAHA.109.902056. Epub 2010 May 10. Circulation. 2010. PMID: 20458013

7

Nesprins LINC the nucleus and cytoskeleton.

Mellad JA, Warren DT, Shanahan CM. Mellad JA, et al. Among authors: shanahan cm. Curr Opin Cell Biol. 2011 Feb;23(1):47-54. doi: 10.1016/j.ceb.2010.11.006. Epub 2010 Dec 20. Curr Opin Cell Biol. 2011. PMID: 21177090 Review.

8

Signalling pathways and vascular calcification.

Liu Y, Shanahan CM. Liu Y, et al. Among authors: shanahan cm. Front Biosci (Landmark Ed). 2011 Jan 1;16(4):1302-14. doi: 10.2741/3790. Front Biosci (Landmark Ed). 2011. PMID: 21196233 Free article. Review.

9

Defective DNA-damage repair induced by nuclear lamina dysfunction is a key mediator of smooth muscle cell aging.

Warren DT, Shanahan CM. Warren DT, et al. Among authors: shanahan cm. Biochem Soc Trans. 2011 Dec;39(6):1780-5. doi: 10.1042/BST20110703. Biochem Soc Trans. 2011. PMID: 22103525 Review.

10

Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells.

Liu Y, Drozdov I, Shroff R, Beltran LE, Shanahan CM. Liu Y, et al. Among authors: shanahan cm. Circ Res. 2013 May 10;112(10):e99-109. doi: 10.1161/CIRCRESAHA.111.300543. Epub 2013 Apr 5. Circ Res. 2013. PMID: 23564641

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