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Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice.
Winbanks CE, Murphy KT, Bernardo BC, Qian H, Liu Y, Sepulveda PV, Beyer C, Hagg A, Thomson RE, Chen JL, Walton KL, Loveland KL, McMullen JR, Rodgers BD, Harrison CA, Lynch GS, Gregorevic P. Winbanks CE, et al. Among authors: sepulveda pv. Sci Transl Med. 2016 Jul 20;8(348):348ra98. doi: 10.1126/scitranslmed.aac4976. Sci Transl Med. 2016. PMID: 27440729
Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin.
Winbanks CE, Weeks KL, Thomson RE, Sepulveda PV, Beyer C, Qian H, Chen JL, Allen JM, Lancaster GI, Febbraio MA, Harrison CA, McMullen JR, Chamberlain JS, Gregorevic P. Winbanks CE, et al. Among authors: sepulveda pv. J Cell Biol. 2012 Jun 25;197(7):997-1008. doi: 10.1083/jcb.201109091. Epub 2012 Jun 18. J Cell Biol. 2012. PMID: 22711699 Free PMC article.
Pharmacology of manipulating lean body mass.
Sepulveda PV, Bush ED, Baar K. Sepulveda PV, et al. Clin Exp Pharmacol Physiol. 2015 Jan;42(1):1-13. doi: 10.1111/1440-1681.12320. Clin Exp Pharmacol Physiol. 2015. PMID: 25311629 Free PMC article. Review.
The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.
Selathurai A, Kowalski GM, Burch ML, Sepulveda P, Risis S, Lee-Young RS, Lamon S, Meikle PJ, Genders AJ, McGee SL, Watt MJ, Russell AP, Frank M, Jackowski S, Febbraio MA, Bruce CR. Selathurai A, et al. Cell Metab. 2015 May 5;21(5):718-30. doi: 10.1016/j.cmet.2015.04.001. Cell Metab. 2015. PMID: 25955207 Free article.
PGC-1α and PGC-1β Increase Protein Synthesis via ERRα in C2C12 Myotubes.
Brown EL, Foletta VC, Wright CR, Sepulveda PV, Konstantopoulos N, Sanigorski A, Della Gatta P, Cameron-Smith D, Kralli A, Russell AP. Brown EL, et al. Among authors: sepulveda pv. Front Physiol. 2018 Sep 25;9:1336. doi: 10.3389/fphys.2018.01336. eCollection 2018. Front Physiol. 2018. PMID: 30356878 Free PMC article.