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Page 1
Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice.
Winbanks CE, Murphy KT, Bernardo BC, Qian H, Liu Y, Sepulveda PV, Beyer C, Hagg A, Thomson RE, Chen JL, Walton KL, Loveland KL, McMullen JR, Rodgers BD, Harrison CA, Lynch GS, Gregorevic P. Winbanks CE, et al. Among authors: mcmullen jr. Sci Transl Med. 2016 Jul 20;8(348):348ra98. doi: 10.1126/scitranslmed.aac4976. Sci Transl Med. 2016. PMID: 27440729
Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction.
Porrello ER, Bell JR, Schertzer JD, Curl CL, McMullen JR, Mellor KM, Ritchie RH, Lynch GS, Harrap SB, Thomas WG, Delbridge LM. Porrello ER, et al. Among authors: mcmullen jr. Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R672-80. doi: 10.1152/ajpregu.90919.2008. Epub 2009 Jan 7. Am J Physiol Regul Integr Comp Physiol. 2009. PMID: 19129376 Free article.
Phosphoinositide 3-kinase p110α is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction.
Weeks KL, Gao X, Du XJ, Boey EJ, Matsumoto A, Bernardo BC, Kiriazis H, Cemerlang N, Tan JW, Tham YK, Franke TF, Qian H, Bogoyevitch MA, Woodcock EA, Febbraio MA, Gregorevic P, McMullen JR. Weeks KL, et al. Among authors: mcmullen jr. Circ Heart Fail. 2012 Jul 1;5(4):523-34. doi: 10.1161/CIRCHEARTFAILURE.112.966622. Epub 2012 Jun 15. Circ Heart Fail. 2012. PMID: 22705768
Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin.
Winbanks CE, Weeks KL, Thomson RE, Sepulveda PV, Beyer C, Qian H, Chen JL, Allen JM, Lancaster GI, Febbraio MA, Harrison CA, McMullen JR, Chamberlain JS, Gregorevic P. Winbanks CE, et al. Among authors: mcmullen jr. J Cell Biol. 2012 Jun 25;197(7):997-1008. doi: 10.1083/jcb.201109091. Epub 2012 Jun 18. J Cell Biol. 2012. PMID: 22711699 Free PMC article.
Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes.
Ritchie RH, Love JE, Huynh K, Bernardo BC, Henstridge DC, Kiriazis H, Tham YK, Sapra G, Qin C, Cemerlang N, Boey EJ, Jandeleit-Dahm K, Du XJ, McMullen JR. Ritchie RH, et al. Among authors: mcmullen jr. Diabetologia. 2012 Dec;55(12):3369-81. doi: 10.1007/s00125-012-2720-0. Epub 2012 Sep 22. Diabetologia. 2012. PMID: 23001375
Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function.
Bernardo BC, Gao XM, Winbanks CE, Boey EJ, Tham YK, Kiriazis H, Gregorevic P, Obad S, Kauppinen S, Du XJ, Lin RC, McMullen JR. Bernardo BC, et al. Among authors: mcmullen jr. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17615-20. doi: 10.1073/pnas.1206432109. Epub 2012 Oct 9. Proc Natl Acad Sci U S A. 2012. PMID: 23047694 Free PMC article.
The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass.
Winbanks CE, Chen JL, Qian H, Liu Y, Bernardo BC, Beyer C, Watt KI, Thomson RE, Connor T, Turner BJ, McMullen JR, Larsson L, McGee SL, Harrison CA, Gregorevic P. Winbanks CE, et al. Among authors: mcmullen jr. J Cell Biol. 2013 Oct 28;203(2):345-57. doi: 10.1083/jcb.201211134. Epub 2013 Oct 21. J Cell Biol. 2013. PMID: 24145169 Free PMC article.
163 results