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Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.
Lamoral-Theys D, Pottier L, Kerff F, Dufrasne F, Proutière F, Wauthoz N, Neven P, Ingrassia L, Antwerpen PV, Lefranc F, Gelbcke M, Pirotte B, Kraus JL, Nève J, Kornienko A, Kiss R, Dubois J. Lamoral-Theys D, et al. Among authors: dufrasne f. Bioorg Med Chem. 2010 Jun 1;18(11):3823-33. doi: 10.1016/j.bmc.2010.04.047. Epub 2010 Apr 21. Bioorg Med Chem. 2010. PMID: 20466556 Free PMC article.
DYRK1A kinase inhibitors with emphasis on cancer.
Ionescu A, Dufrasne F, Gelbcke M, Jabin I, Kiss R, Lamoral-Theys D. Ionescu A, et al. Among authors: dufrasne f. Mini Rev Med Chem. 2012 Nov;12(13):1315-29. doi: 10.2174/13895575112091315. Mini Rev Med Chem. 2012. PMID: 23016545 Review.
Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors.
Soubhye J, Aldib I, Elfving B, Gelbcke M, Furtmüller PG, Podrecca M, Conotte R, Colet JM, Rousseau A, Reye F, Sarakbi A, Vanhaeverbeek M, Kauffmann JM, Obinger C, Nève J, Prévost M, Zouaoui Boudjeltia K, Dufrasne F, Van Antwerpen P. Soubhye J, et al. Among authors: dufrasne f. J Med Chem. 2013 May 23;56(10):3943-58. doi: 10.1021/jm4001538. Epub 2013 May 6. J Med Chem. 2013. PMID: 23581551
Hybrid molecules inhibiting myeloperoxidase activity and serotonin reuptake: a possible new approach of major depressive disorders with inflammatory syndrome.
Soubhye J, Aldib I, Prévost M, Elfving B, Gelbcke M, Podrecca M, Conotte R, Colet JM, Furtmüller PG, Delporte C, Rousseau A, Vanhaeverbeek M, Nève J, Obinger C, Zouaoui-Boudjeltia K, Van Antwerpen P, Dufrasne F. Soubhye J, et al. Among authors: dufrasne f. J Pharm Pharmacol. 2014 Aug;66(8):1122-32. doi: 10.1111/jphp.12236. Epub 2014 Mar 27. J Pharm Pharmacol. 2014. PMID: 24673477
68 results