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FAIM-L is an IAP-binding protein that inhibits XIAP ubiquitinylation and protects from Fas-induced apoptosis.
Moubarak RS, Planells-Ferrer L, Urresti J, Reix S, Segura MF, Carriba P, Marqués-Fernàndez F, Sole C, Llecha-Cano N, Lopez-Soriano J, Sanchis D, Yuste VJ, Comella JX. Moubarak RS, et al. Among authors: planells ferrer l. J Neurosci. 2013 Dec 4;33(49):19262-75. doi: 10.1523/JNEUROSCI.2479-13.2013. J Neurosci. 2013. PMID: 24305822 Free PMC article.
Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells.
Urresti J, Ruiz-Meana M, Coccia E, Arévalo JC, Castellano J, Fernández-Sanz C, Galenkamp KM, Planells-Ferrer L, Moubarak RS, Llecha-Cano N, Reix S, García-Dorado D, Barneda-Zahonero B, Comella JX. Urresti J, et al. Among authors: planells ferrer l. J Biol Chem. 2016 Jan 15;291(3):1221-34. doi: 10.1074/jbc.M115.677682. Epub 2015 Nov 18. J Biol Chem. 2016. PMID: 26582200 Free PMC article.
SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
Coccia E, Planells-Ferrer L, Badillos-Rodríguez R, Pascual M, Segura MF, Fernández-Hernández R, López-Soriano J, Garí E, Soriano E, Barneda-Zahonero B, Moubarak RS, Pérez-García MJ, Comella JX. Coccia E, et al. Among authors: planells ferrer l. Cell Death Dis. 2020 Feb 3;11(2):82. doi: 10.1038/s41419-020-2282-x. Cell Death Dis. 2020. PMID: 32015347 Free PMC article.
TNFα induces survival through the FLIP-L-dependent activation of the MAPK/ERK pathway.
Marques-Fernandez F, Planells-Ferrer L, Gozzelino R, Galenkamp KM, Reix S, Llecha-Cano N, Lopez-Soriano J, Yuste VJ, Moubarak RS, Comella JX. Marques-Fernandez F, et al. Among authors: planells ferrer l. Cell Death Dis. 2013 Feb 14;4(2):e493. doi: 10.1038/cddis.2013.25. Cell Death Dis. 2013. PMID: 23412386 Free PMC article.
MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness.
Planells-Ferrer L, Urresti J, Soriano A, Reix S, Murphy DM, Ferreres JC, Borràs F, Gallego S, Stallings RL, Moubarak RS, Segura MF, Comella JX. Planells-Ferrer L, et al. Cell Death Dis. 2014 Sep 4;5(9):e1401. doi: 10.1038/cddis.2014.356. Cell Death Dis. 2014. PMID: 25188511 Free PMC article.
BRG1/SMARCA4 is essential for neuroblastoma cell viability through modulation of cell death and survival pathways.
Jubierre L, Soriano A, Planells-Ferrer L, París-Coderch L, Tenbaum SP, Romero OA, Moubarak RS, Almazán-Moga A, Molist C, Roma J, Navarro S, Noguera R, Sánchez-Céspedes M, Comella JX, Palmer HG, Sánchez de Toledo J, Gallego S, Segura MF. Jubierre L, et al. Among authors: planells ferrer l. Oncogene. 2016 Sep 29;35(39):5179-90. doi: 10.1038/onc.2016.50. Epub 2016 Mar 21. Oncogene. 2016. PMID: 26996667