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Evidence of luminal phosphatidylcholine secretion in rat ileum.
Ehehalt R, Jochims C, Lehmann WD, Erben G, Staffer S, Reininger C, Stremmel W. Ehehalt R, et al. Among authors: staffer s. Biochim Biophys Acta. 2004 Jun 1;1682(1-3):63-71. doi: 10.1016/j.bbalip.2004.01.009. Biochim Biophys Acta. 2004. PMID: 15158757
Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis.
Stremmel W, Staffer S, Wannhoff A, Pathil A, Chamulitrat W. Stremmel W, et al. Among authors: staffer s. FASEB J. 2014 Jul;28(7):3159-70. doi: 10.1096/fj.14-249763. Epub 2014 Apr 9. FASEB J. 2014. PMID: 24719358
Thus, iPLA2beta acts as an upstream checkpoint for mechanisms that regulate fatty acid uptake, and its inhibition by UDCA-LPE qualifies this nontoxic compound as a therapeutic candidate for the treatment of NASH.-Stremmel, W., Staffer, S., Wannhoff, A., Pathil, A., …
Thus, iPLA2beta acts as an upstream checkpoint for mechanisms that regulate fatty acid uptake, and its inhibition by UDCA-LPE qualifies this …
iPla2β deficiency in mice fed with MCD diet does not correct the defect of phospholipid remodeling but attenuates hepatocellular injury via an inhibition of lipid uptake genes.
Zhu X, Gan-Schreier H, Otto AC, Cheng Y, Staffer S, Tuma-Kellner S, Ganzha A, Liebisch G, Chamulitrat W. Zhu X, et al. Among authors: staffer s. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):677-687. doi: 10.1016/j.bbalip.2019.02.003. Epub 2019 Feb 5. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30735854
Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling.
Otto AC, Gan-Schreier H, Zhu X, Tuma-Kellner S, Staffer S, Ganzha A, Liebisch G, Chamulitrat W. Otto AC, et al. Among authors: staffer s. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):662-676. doi: 10.1016/j.bbalip.2019.01.012. Epub 2019 Feb 5. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30735855
21 results