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Page 1
Design, synthesis, and In vitro antituberculosis activity of 2(5H)-Furanone derivatives.
Ngwane AH, Panayides JL, Chouteau F, Macingwana L, Viljoen A, Baker B, Madikane E, de Kock C, Wiesner L, Chibale K, Parkinson CJ, Mmutlane EM, van Helden P, Wiid I. Ngwane AH, et al. Among authors: wiesner l. IUBMB Life. 2016 Aug;68(8):612-20. doi: 10.1002/iub.1526. Epub 2016 Jun 27. IUBMB Life. 2016. PMID: 27346745 Free article.
2,4-Diaminothienopyrimidines as orally active antimalarial agents.
González Cabrera D, Le Manach C, Douelle F, Younis Y, Feng TS, Paquet T, Nchinda AT, Street LJ, Taylor D, de Kock C, Wiesner L, Duffy S, White KL, Zabiulla KM, Sambandan Y, Bashyam S, Waterson D, Witty MJ, Charman SA, Avery VM, Wittlin S, Chibale K. González Cabrera D, et al. Among authors: wiesner l. J Med Chem. 2014 Feb 13;57(3):1014-22. doi: 10.1021/jm401760c. Epub 2014 Jan 28. J Med Chem. 2014. PMID: 24446664
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.
Le Manach C, Gonzàlez Cabrera D, Douelle F, Nchinda AT, Younis Y, Taylor D, Wiesner L, White KL, Ryan E, March C, Duffy S, Avery VM, Waterson D, Witty MJ, Wittlin S, Charman SA, Street LJ, Chibale K. Le Manach C, et al. Among authors: wiesner l. J Med Chem. 2014 Mar 27;57(6):2789-98. doi: 10.1021/jm500098s. Epub 2014 Mar 13. J Med Chem. 2014. PMID: 24568587
Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.
Tukulula M, Njoroge M, Abay ET, Mugumbate GC, Wiesner L, Taylor D, Gibhard L, Norman J, Swart KJ, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Kameni-Tcheudji J, Chibale K. Tukulula M, et al. Among authors: wiesner l. ACS Med Chem Lett. 2013 Oct 1;4(12):1198-202. doi: 10.1021/ml400311r. eCollection 2013 Dec 12. ACS Med Chem Lett. 2013. PMID: 24900630 Free PMC article.
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: part 2.
Le Manach C, Paquet T, Gonzàlez Cabrera D, Younis Y, Taylor D, Wiesner L, Lawrence N, Schwager S, Waterson D, Witty MJ, Wittlin S, Street LJ, Chibale K. Le Manach C, et al. Among authors: wiesner l. J Med Chem. 2014 Nov 13;57(21):8839-48. doi: 10.1021/jm500887k. Epub 2014 Oct 23. J Med Chem. 2014. PMID: 25313449
Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice.
Melariri P, Kalombo L, Nkuna P, Dube A, Hayeshi R, Ogutu B, Gibhard L, deKock C, Smith P, Wiesner L, Swai H. Melariri P, et al. Among authors: wiesner l. Int J Nanomedicine. 2015 Feb 20;10:1493-503. doi: 10.2147/IJN.S76317. eCollection 2015. Int J Nanomedicine. 2015. PMID: 25759576 Free PMC article.
307 results