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Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes.
Hinchliffe P, González MM, Mojica MF, González JM, Castillo V, Saiz C, Kosmopoulou M, Tooke CL, Llarrull LI, Mahler G, Bonomo RA, Vila AJ, Spencer J. Hinchliffe P, et al. Among authors: tooke cl. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3745-54. doi: 10.1073/pnas.1601368113. Epub 2016 Jun 14. Proc Natl Acad Sci U S A. 2016. PMID: 27303030 Free PMC article.
Molecular Basis of Class A β-Lactamase Inhibition by Relebactam.
Tooke CL, Hinchliffe P, Lang PA, Mulholland AJ, Brem J, Schofield CJ, Spencer J. Tooke CL, et al. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e00564-19. doi: 10.1128/AAC.00564-19. Print 2019 Oct. Antimicrob Agents Chemother. 2019. PMID: 31383664 Free PMC article.
Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition.
Hinchliffe P, Tooke CL, Bethel CR, Wang B, Arthur C, Heesom KJ, Shapiro S, Schlatzer DM, Papp-Wallace KM, Bonomo RA, Spencer J. Hinchliffe P, et al. Among authors: tooke cl. mBio. 2022 Jun 28;13(3):e0179321. doi: 10.1128/mbio.01793-21. Epub 2022 May 25. mBio. 2022. PMID: 35612361 Free PMC article.
β-Lactamases and β-Lactamase Inhibitors in the 21st Century.
Tooke CL, Hinchliffe P, Bragginton EC, Colenso CK, Hirvonen VHA, Takebayashi Y, Spencer J. Tooke CL, et al. J Mol Biol. 2019 Aug 23;431(18):3472-3500. doi: 10.1016/j.jmb.2019.04.002. Epub 2019 Apr 5. J Mol Biol. 2019. PMID: 30959050 Free PMC article. Review.
Profiling interactions of vaborbactam with metallo-β-lactamases.
Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J. Langley GW, et al. Among authors: tooke cl. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1981-1984. doi: 10.1016/j.bmcl.2019.05.031. Epub 2019 May 17. Bioorg Med Chem Lett. 2019. PMID: 31171422 Free PMC article.
Faropenem reacts with serine and metallo-β-lactamases to give multiple products.
Lucic A, Hinchliffe P, Malla TR, Tooke CL, Brem J, Calvopiña K, Lohans CT, Rabe P, McDonough MA, Armistead T, Orville AM, Spencer J, Schofield CJ. Lucic A, et al. Among authors: tooke cl. Eur J Med Chem. 2021 Apr 5;215:113257. doi: 10.1016/j.ejmech.2021.113257. Epub 2021 Feb 9. Eur J Med Chem. 2021. PMID: 33618159 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33460928
18 results