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Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.
Lu J, Qian Y, Altieri M, Dong H, Wang J, Raina K, Hines J, Winkler JD, Crew AP, Coleman K, Crews CM. Lu J, et al. Among authors: winkler jd. Chem Biol. 2015 Jun 18;22(6):755-63. doi: 10.1016/j.chembiol.2015.05.009. Epub 2015 Jun 4. Chem Biol. 2015. PMID: 26051217 Free PMC article.
Targeted protein degradation by PROTACs.
Neklesa TK, Winkler JD, Crews CM. Neklesa TK, et al. Among authors: winkler jd. Pharmacol Ther. 2017 Jun;174:138-144. doi: 10.1016/j.pharmthera.2017.02.027. Epub 2017 Feb 14. Pharmacol Ther. 2017. PMID: 28223226 Review.
Low-dose biliatresone treatment of pregnant mice causes subclinical biliary disease in their offspring: Evidence for a spectrum of neonatal injury.
Gupta K, Xu JP, Diamond T, de Jong IEM, Glass A, Llewellyn J, Theise ND, Waisbourd-Zinman O, Winkler JD, Behrens EM, Mesaros C, Wells RG. Gupta K, et al. Among authors: winkler jd. PLoS One. 2024 Apr 5;19(4):e0301824. doi: 10.1371/journal.pone.0301824. eCollection 2024. PLoS One. 2024. PMID: 38578745 Free PMC article.
Lysosomal lipid peroxidation regulates tumor immunity.
Bhardwaj M, Lee JJ, Versace AM, Harper SL, Goldman AR, Crissey MAS, Jain V, Singh MP, Vernon M, Aplin AE, Lee S, Morita M, Winkler JD, Liu Q, Speicher DW, Amaravadi RK. Bhardwaj M, et al. Among authors: winkler jd. J Clin Invest. 2023 Apr 17;133(8):e164596. doi: 10.1172/JCI164596. J Clin Invest. 2023. PMID: 36795483 Free PMC article.
PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma.
Sharma G, Ojha R, Noguera-Ortega E, Rebecca VW, Attanasio J, Liu S, Piao S, Lee JJ, Nicastri MC, Harper SL, Ronghe A, Jain V, Winkler JD, Speicher DW, Mastio J, Gimotty PA, Xu X, Wherry EJ, Gabrilovich DI, Amaravadi RK. Sharma G, et al. Among authors: winkler jd. JCI Insight. 2022 Oct 24;7(20):e165688. doi: 10.1172/jci.insight.165688. JCI Insight. 2022. PMID: 36278493 Free PMC article. No abstract available.
Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors.
Diamond JR, Pitts TM, Ungermannova D, Nasveschuk CG, Zhang G, Phillips AJ, Bagby SM, Pafford J, Yacob BW, Newton TP, Tentler JJ, Gittleman B, Hartman SJ, DeMattei JA, Winkler JD, Wendt MK, Schiemann WP, Eckhardt SG, Liu X, Piscopio AD. Diamond JR, et al. Among authors: winkler jd. Mol Cancer Ther. 2022 Mar 1;21(3):397-406. doi: 10.1158/1535-7163.MCT-21-0455. Mol Cancer Ther. 2022. PMID: 34965958 Free PMC article.
Synthesis of Cyclohexane-Angularly-Fused Triquinanes.
Jeon H, Winkler JD. Jeon H, et al. Among authors: winkler jd. Synthesis (Stuttg). 2021;53(3):475-488. doi: 10.1055/s-0040-1705953. Epub 2020 Nov 3. Synthesis (Stuttg). 2021. PMID: 34334830 Free PMC article.
164 results