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Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients With Missense AIP Mutations.
Hernández-Ramírez LC, Martucci F, Morgan RM, Trivellin G, Tilley D, Ramos-Guajardo N, Iacovazzo D, D'Acquisto F, Prodromou C, Korbonits M. Hernández-Ramírez LC, et al. Among authors: prodromou c. J Clin Endocrinol Metab. 2016 Aug;101(8):3144-54. doi: 10.1210/jc.2016-1307. Epub 2016 Jun 2. J Clin Endocrinol Metab. 2016. PMID: 27253664 Free PMC article.
Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes.
Morgan RM, Pal M, Roe SM, Pearl LH, Prodromou C. Morgan RM, et al. Among authors: prodromou c. Acta Crystallogr D Biol Crystallogr. 2015 May;71(Pt 5):1197-206. doi: 10.1107/S1399004715004551. Epub 2015 Apr 25. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 25945584 Free PMC article.
c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells.
Dunn DM, Woodford MR, Truman AW, Jensen SM, Schulman J, Caza T, Remillard TC, Loiselle D, Wolfgeher D, Blagg BS, Franco L, Haystead TA, Daturpalli S, Mayer MP, Trepel JB, Morgan RM, Prodromou C, Kron SJ, Panaretou B, Stetler-Stevenson WG, Landas SK, Neckers L, Bratslavsky G, Bourboulia D, Mollapour M. Dunn DM, et al. Among authors: prodromou c. Cell Rep. 2015 Aug 11;12(6):1006-18. doi: 10.1016/j.celrep.2015.07.004. Epub 2015 Jul 30. Cell Rep. 2015. PMID: 26235616 Free PMC article.
In vivo bioassay to test the pathogenicity of missense human AIP variants.
Aflorei ED, Klapholz B, Chen C, Radian S, Dragu AN, Moderau N, Prodromou C, Ribeiro PS, Stanewsky R, Korbonits M. Aflorei ED, et al. Among authors: prodromou c. J Med Genet. 2018 Aug;55(8):522-529. doi: 10.1136/jmedgenet-2017-105191. Epub 2018 Apr 9. J Med Genet. 2018. PMID: 29632148 Free PMC article.
Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M. Woodford MR, et al. Among authors: prodromou c. EMBO J. 2017 Dec 15;36(24):3650-3665. doi: 10.15252/embj.201796700. Epub 2017 Nov 10. EMBO J. 2017. PMID: 29127155 Free PMC article.
Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90.
Sager RA, Woodford MR, Backe SJ, Makedon AM, Baker-Williams AJ, DiGregorio BT, Loiselle DR, Haystead TA, Zachara NE, Prodromou C, Bourboulia D, Schmidt LS, Linehan WM, Bratslavsky G, Mollapour M. Sager RA, et al. Among authors: prodromou c. Cell Rep. 2019 Jan 29;26(5):1344-1356.e5. doi: 10.1016/j.celrep.2019.01.018. Cell Rep. 2019. PMID: 30699359 Free PMC article.
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
Woodford MR, Dunn DM, Blanden AR, Capriotti D, Loiselle D, Prodromou C, Panaretou B, Hughes PF, Smith A, Ackerman W, Haystead TA, Loh SN, Bourboulia D, Schmidt LS, Marston Linehan W, Bratslavsky G, Mollapour M. Woodford MR, et al. Among authors: prodromou c. Nat Commun. 2016 Jun 29;7:12037. doi: 10.1038/ncomms12037. Nat Commun. 2016. PMID: 27353360 Free PMC article.
129 results