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An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine.
Barron SC, McLaughlin JT, See JA, Richards VL, Rosenberg RL. Barron SC, et al. Mol Pharmacol. 2009 Aug;76(2):253-63. doi: 10.1124/mol.109.056226. Epub 2009 May 1. Mol Pharmacol. 2009. PMID: 19411608 Free PMC article.