Laufer S - Search Results

1

A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.

Dauch D, Rudalska R, Cossa G, Nault JC, Kang TW, Wuestefeld T, Hohmeyer A, Imbeaud S, Yevsa T, Hoenicke L, Pantsar T, Bozko P, Malek NP, Longerich T, Laufer S, Poso A, Zucman-Rossi J, Eilers M, Zender L. Dauch D, et al. Among authors: laufer s. Nat Med. 2016 Jul;22(7):744-53. doi: 10.1038/nm.4107. Epub 2016 May 23. Nat Med. 2016. PMID: 27213815

2

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

Rudalska R, Dauch D, Longerich T, McJunkin K, Wuestefeld T, Kang TW, Hohmeyer A, Pesic M, Leibold J, von Thun A, Schirmacher P, Zuber J, Weiss KH, Powers S, Malek NP, Eilers M, Sipos B, Lowe SW, Geffers R, Laufer S, Zender L. Rudalska R, et al. Among authors: laufer s. Nat Med. 2014 Oct;20(10):1138-46. doi: 10.1038/nm.3679. Epub 2014 Sep 14. Nat Med. 2014. PMID: 25216638 Free PMC article.

3

Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.

Wentsch HK, Walter NM, Bührmann M, Mayer-Wrangowski S, Rauh D, Zaman GJR, Willemsen-Seegers N, Buijsman RC, Henning M, Dauch D, Zender L, Laufer S. Wentsch HK, et al. Among authors: laufer s. Angew Chem Int Ed Engl. 2017 May 2;56(19):5363-5367. doi: 10.1002/anie.201701185. Epub 2017 Apr 11. Angew Chem Int Ed Engl. 2017. PMID: 28397331

4

Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors.

Heider F, Ansideri F, Tesch R, Pantsar T, Haun U, Döring E, Kudolo M, Poso A, Albrecht W, Laufer SA, Koch P. Heider F, et al. Eur J Med Chem. 2019 Aug 1;175:309-329. doi: 10.1016/j.ejmech.2019.04.035. Epub 2019 Apr 24. Eur J Med Chem. 2019. PMID: 31096153

5

Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen Synthase Kinase-3β Inhibitors.

Andreev S, Pantsar T, Ansideri F, Kudolo M, Forster M, Schollmeyer D, Laufer SA, Koch P. Andreev S, et al. Among authors: laufer sa. Molecules. 2019 Jun 25;24(12):2331. doi: 10.3390/molecules24122331. Molecules. 2019. PMID: 31242571 Free PMC article.

6

Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors.

Pedreira JGB, Nahidino P, Kudolo M, Pantsar T, Berger BT, Forster M, Knapp S, Laufer S, Barreiro EJ. Pedreira JGB, et al. Among authors: laufer s. J Med Chem. 2020 Jul 9;63(13):7347-7354. doi: 10.1021/acs.jmedchem.0c00508. Epub 2020 Jun 11. J Med Chem. 2020. PMID: 32462866

7

Selective targeting of the αC and DFG-out pocket in p38 MAPK.

Röhm S, Schröder M, Dwyer JE, Widdowson CS, Chaikuad A, Berger BT, Joerger AC, Krämer A, Harbig J, Dauch D, Kudolo M, Laufer S, Bagley MC, Knapp S. Röhm S, et al. Among authors: laufer s. Eur J Med Chem. 2020 Dec 15;208:112721. doi: 10.1016/j.ejmech.2020.112721. Epub 2020 Aug 20. Eur J Med Chem. 2020. PMID: 33035818

8

Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4.

Kircher T, Pantsar T, Oder A, Peter von Kries J, Juchum M, Pfaffenrot B, Kloevekorn P, Albrecht W, Selig R, Laufer S. Kircher T, et al. Among authors: laufer s. Eur J Med Chem. 2021 Jan 1;209:112901. doi: 10.1016/j.ejmech.2020.112901. Epub 2020 Oct 4. Eur J Med Chem. 2021. PMID: 33092905

9

From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4).

Klövekorn P, Pfaffenrot B, Juchum M, Selig R, Albrecht W, Zender L, Laufer SA. Klövekorn P, et al. Eur J Med Chem. 2021 Jan 15;210:112963. doi: 10.1016/j.ejmech.2020.112963. Epub 2020 Oct 24. Eur J Med Chem. 2021. PMID: 33199152

10

Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration.

Pfaffenrot B, Klövekorn P, Juchum M, Selig R, Albrecht W, Zender L, Laufer SA. Pfaffenrot B, et al. Eur J Med Chem. 2021 Jun 5;218:113371. doi: 10.1016/j.ejmech.2021.113371. Epub 2021 Mar 17. Eur J Med Chem. 2021. PMID: 33794385

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

531 results

Search Page