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One-Step Synthetic Access to Isosteric and Potent Anticancer Nitrogen Heterocycles with the Benzo[c]phenanthridine Scaffold.
Chemistry. 2016 Jun 6;22(24):8301-8. doi: 10.1002/chem.201600308. Epub 2016 May 6.
Chemistry. 2016.
PMID: 27151929
Triggering the directional selectivity of a ring-closure reaction leads to pyridoazacarbazoles with anticancer properties.
Steinhauer TN, Längle DS, Meier C, Girreser U, Stenzel L, Heber D, Clement B.
Steinhauer TN, et al.
Chemistry. 2015 Apr 27;21(18):6668-72. doi: 10.1002/chem.201500156. Epub 2015 Mar 30.
Chemistry. 2015.
PMID: 25825166
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11-Substituted Benzo[c]phenanthridines: New Structures and Insight into Their Mode of Antiproliferative Action.
Clement B, Girreser U, Steinhauer TN, Meier C, Marko D, Aichinger G, Kaltefleiter I, Stenzel L, Heber D, Weide M, Wolschendorf U, Zebothsen I, Zur Nieden D.
Clement B, et al. Among authors: steinhauer tn.
ChemMedChem. 2016 Oct 6;11(19):2155-2170. doi: 10.1002/cmdc.201600199. Epub 2016 Aug 22.
ChemMedChem. 2016.
PMID: 27546098
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A Dual Topoisomerase Inhibitor of Intense Pro-Apoptotic and Antileukemic Nature for Cancer Treatment.
Meier C, Steinhauer TN, Koczian F, Plitzko B, Jarolim K, Girreser U, Braig S, Marko D, Vollmar AM, Clement B.
Meier C, et al. Among authors: steinhauer tn.
ChemMedChem. 2017 Mar 7;12(5):347-352. doi: 10.1002/cmdc.201700026. Epub 2017 Feb 8.
ChemMedChem. 2017.
PMID: 28099785
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The Aza-Analogous Benzo[c]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties.
Aichinger G, Lichtenberger FB, Steinhauer TN, Flörkemeier I, Del Favero G, Clement B, Marko D.
Aichinger G, et al. Among authors: steinhauer tn.
Molecules. 2020 Mar 27;25(7):1524. doi: 10.3390/molecules25071524.
Molecules. 2020.
PMID: 32230817
Free PMC article.
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Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer.
Flörkemeier I, Steinhauer TN, Hedemann N, Ölander M, Artursson P, Clement B, Bauerschlag DO.
Flörkemeier I, et al. Among authors: steinhauer tn.
Ther Adv Med Oncol. 2021 Nov 25;13:17588359211059896. doi: 10.1177/17588359211059896. eCollection 2021.
Ther Adv Med Oncol. 2021.
PMID: 34887943
Free PMC article.
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High Antitumor Activity of the Dual Topoisomerase Inhibitor P8-D6 in Breast Cancer.
Flörkemeier I, Steinhauer TN, Hedemann N, Weimer JP, Rogmans C, van Mackelenbergh MT, Maass N, Clement B, Bauerschlag DO.
Flörkemeier I, et al. Among authors: steinhauer tn.
Cancers (Basel). 2021 Dec 21;14(1):2. doi: 10.3390/cancers14010002.
Cancers (Basel). 2021.
PMID: 35008166
Free PMC article.
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