APLNR is involved in ATRA-induced growth inhibition of nasopharyngeal carcinoma and may suppress EMT through PI3K-Akt-mTOR signaling.
Liu Y, Liu Q, Chen S, Liu Y, Huang Y, Chen P, Li X, Gao G, Xu K, Fan S, Zeng Z, Xiong W, Tan M, Li G, Zhang W.
Liu Y, et al. Among authors: gao g.
FASEB J. 2019 Nov;33(11):11959-11972. doi: 10.1096/fj.201802416RR. Epub 2019 Aug 13.
FASEB J. 2019.
PMID: 31408612
Consistently, after treatment with all-trans-RA (ATRA), we found that APLNR was significantly up-regulated in NPC cell lines (5-8F and HNE1), and proliferation of NPC cells was inhibited. Cell cycle arrest occurred in the G(0)/G(1) phase. In contrast, knockdown of A …
Consistently, after treatment with all-trans-RA (ATRA), we found that APLNR was significantly up-regulated in NPC cell lines (5-8F and HNE1) …