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GQ-16, a TZD-Derived Partial PPARγ Agonist, Induces the Expression of Thermogenesis-Related Genes in Brown Fat and Visceral White Fat and Decreases Visceral Adiposity in Obese and Hyperglycemic Mice.
Coelho MS, de Lima CL, Royer C, Silva JB, Oliveira FC, Christ CG, Pereira SA, Bao SN, Lima MC, Pitta MG, Pitta IR, Neves FA, Amato AA. Coelho MS, et al. Among authors: amato aa. PLoS One. 2016 May 3;11(5):e0154310. doi: 10.1371/journal.pone.0154310. eCollection 2016. PLoS One. 2016. PMID: 27138164 Free PMC article.
GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain.
Amato AA, Rajagopalan S, Lin JZ, Carvalho BM, Figueira AC, Lu J, Ayers SD, Mottin M, Silveira RL, Souza PC, Mourão RH, Saad MJ, Togashi M, Simeoni LA, Abdalla DS, Skaf MS, Polikparpov I, Lima MC, Galdino SL, Brennan RG, Baxter JD, Pitta IR, Webb P, Phillips KJ, Neves FA. Amato AA, et al. J Biol Chem. 2012 Aug 10;287(33):28169-79. doi: 10.1074/jbc.M111.332106. Epub 2012 May 14. J Biol Chem. 2012. PMID: 22584573 Free PMC article.
Chemical synthesis, docking studies and biological effects of a pan peroxisome proliferator-activated receptor agonist and cyclooxygenase inhibitor.
Santin JR, Uchôa FD, Lima Mdo C, Rabello MM, Machado ID, Hernandes MZ, Amato AA, Milton FA, Webb P, Neves Fde A, Galdino SL, Pitta IR, Farsky SH. Santin JR, et al. Among authors: amato aa. Eur J Pharm Sci. 2013 Mar 12;48(4-5):689-97. doi: 10.1016/j.ejps.2012.12.029. Epub 2013 Jan 7. Eur J Pharm Sci. 2013. PMID: 23305993
PPARγ partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes.
Milton FA, Cvoro A, Amato AA, Sieglaff DH, Filgueira CS, Arumanayagam AS, de Lima Mdo C, Pitta IR, de Assis Rocha Neves F, Webb P. Milton FA, et al. Among authors: amato aa. Biochem Biophys Res Commun. 2015 Aug 28;464(3):718-23. doi: 10.1016/j.bbrc.2015.07.011. Epub 2015 Jul 10. Biochem Biophys Res Commun. 2015. PMID: 26168725
276 results