Carrothers TJ - Search Results

1

Model-Supported Development of CS-8635: A Fixed-Dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide.

Song S, Carrothers TJ, Moore H, Green M, Miller R, Rohatagi S, Lee J, Wang A, Melino M, Patel M, Heyrman R, Salazar DE. Song S, et al. Among authors: carrothers tj. Clin Pharmacol Drug Dev. 2013 Apr;2(2):103-12. doi: 10.1002/cpdd.17. Epub 2013 Mar 16. Clin Pharmacol Drug Dev. 2013. PMID: 27121665

2

Evaluation of population pharmacokinetics and exposure-response relationship with coadministration of amlodipine besylate and olmesartan medoxomil.

Rohatagi S, Carrothers TJ, Kshirsagar S, Khariton T, Lee J, Salazar D. Rohatagi S, et al. Among authors: carrothers tj. J Clin Pharmacol. 2008 Jul;48(7):823-36. doi: 10.1177/0091270008317847. Epub 2008 May 19. J Clin Pharmacol. 2008. PMID: 18490496 Clinical Trial.

3

Model-based development of a PPARgamma agonist, rivoglitazone, to aid dose selection and optimize clinical trial designs.

Rohatagi S, Carrothers TJ, Jin J, Jusko WJ, Khariton T, Walker J, Truitt K, Salazar DE. Rohatagi S, et al. Among authors: carrothers tj. J Clin Pharmacol. 2008 Dec;48(12):1420-9. doi: 10.1177/0091270008323260. Epub 2008 Oct 20. J Clin Pharmacol. 2008. PMID: 18936283 Clinical Trial.

4

Use of an exposure-response model to aid early drug development of an oral sphingosine 1-phosphate receptor modulator.

Rohatagi S, Zahir H, Moberly JB, Truitt KE, Inaba S, Shimozato T, Carrothers TJ. Rohatagi S, et al. Among authors: carrothers tj. J Clin Pharmacol. 2009 Jan;49(1):50-62. doi: 10.1177/0091270008325672. Epub 2008 Oct 23. J Clin Pharmacol. 2009. PMID: 18948412 Clinical Trial.

5

Is a thorough QTc study necessary? The role of modeling and simulation in evaluating the QTc prolongation potential of drugs.

Rohatagi S, Carrothers TJ, Kuwabara-Wagg J, Khariton T. Rohatagi S, et al. Among authors: carrothers tj. J Clin Pharmacol. 2009 Nov;49(11):1284-96. doi: 10.1177/0091270009341184. Epub 2009 Sep 4. J Clin Pharmacol. 2009. PMID: 19734373

6

Population pharmacokinetic model for a novel oral hypoglycemic formed in vivo: comparing the use of active metabolite data alone versus using data of upstream and downstream metabolites.

Kastrissios H, Walker JR, Carrothers TJ, Kshirsagar S, Khariton T, Habtemariam B, Mager DE, Rohatagi S. Kastrissios H, et al. Among authors: carrothers tj. J Clin Pharmacol. 2012 Mar;52(3):404-15. doi: 10.1177/0091270010396373. Epub 2011 Mar 21. J Clin Pharmacol. 2012. PMID: 21422240

7

The use of modeling and simulation to guide clinical development of olmesartan medoxomil in pediatric subjects.

Salazar DE, Song SH, Shi J, Rohatagi S, Heyrman R, Wada DR, Carrothers TJ. Salazar DE, et al. Among authors: carrothers tj. Clin Pharmacol Ther. 2012 Feb;91(2):250-6. doi: 10.1038/clpt.2011.220. Epub 2011 Dec 28. Clin Pharmacol Ther. 2012. PMID: 22205195

8

Modelling and simulation of edoxaban exposure and response relationships in patients with atrial fibrillation.

Salazar DE, Mendell J, Kastrissios H, Green M, Carrothers TJ, Song S, Patel I, Bocanegra TS, Antman EM, Giugliano RP, Kunitada S, Dornseif B, Shi M, Tachibana M, Zhou S, Rohatagi S. Salazar DE, et al. Among authors: carrothers tj. Thromb Haemost. 2012 May;107(5):925-36. doi: 10.1160/TH11-08-0566. Epub 2012 Mar 8. Thromb Haemost. 2012. PMID: 22398655 Clinical Trial.

9

Effects of Trastuzumab Emtansine (T-DM1) on QT Interval and Safety of Pertuzumab Plus T-DM1 in Patients With Previously Treated Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer.

Gupta M, Wang B, Carrothers TJ, LoRusso PM, Chu YW, Shih T, Loecke D, Joshi A, Saad O, Yi JH, Girish S. Gupta M, et al. Among authors: carrothers tj. Clin Pharmacol Drug Dev. 2013 Jan;2(1):11-24. doi: 10.1002/cpdd.9. Epub 2013 Feb 26. Clin Pharmacol Drug Dev. 2013. PMID: 27121556

10

Dalbavancin Population Pharmacokinetic Modeling and Target Attainment Analysis.

Carrothers TJ, Chittenden JT, Critchley I. Carrothers TJ, et al. Clin Pharmacol Drug Dev. 2020 Jan;9(1):21-31. doi: 10.1002/cpdd.695. Epub 2019 May 14. Clin Pharmacol Drug Dev. 2020. PMID: 31087630 Free PMC article. Clinical Trial.

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