Olsen D - Search Results

1

2'-Modified Guanosine Analogs for the Treatment of HCV.

Girijavallabhan V, Arasappan A, Bennett F, Chen K, Dang Q, Huang Y, Kerekes A, Nair L, Pissarnitski D, Verma V, Alvarez C, Chen P, Cole D, Esposite S, Huang Y, Hong Q, Liu Z, Pan W, Pu H, Rossman R, Truong Q, Vibulbhan B, Wang J, Zhao Z, Olsen D, Stamford A, Bogen S, Njoroge FG. Girijavallabhan V, et al. Among authors: olsen d. Nucleosides Nucleotides Nucleic Acids. 2016 Jun 2;35(6):277-94. doi: 10.1080/15257770.2016.1154968. Epub 2016 Apr 22. Nucleosides Nucleotides Nucleic Acids. 2016. PMID: 27104963

2

Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs.

Carroll SS, Tomassini JE, Bosserman M, Getty K, Stahlhut MW, Eldrup AB, Bhat B, Hall D, Simcoe AL, LaFemina R, Rutkowski CA, Wolanski B, Yang Z, Migliaccio G, De Francesco R, Kuo LC, MacCoss M, Olsen DB. Carroll SS, et al. Among authors: olsen db. J Biol Chem. 2003 Apr 4;278(14):11979-84. doi: 10.1074/jbc.M210914200. Epub 2003 Jan 27. J Biol Chem. 2003. PMID: 12554735 Free article.

3

Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876.

McComas CC, Palani A, Chang W, Holloway MK, Lesburg CA, Li P, Liverton N, Meinke PT, Olsen DB, Peng X, Soll RM, Ummat A, Wu J, Wu J, Zorn N, Ludmerer SW. McComas CC, et al. ChemMedChem. 2017 Sep 7;12(17):1436-1448. doi: 10.1002/cmdc.201700228. Epub 2017 Jul 25. ChemMedChem. 2017. PMID: 28741898

4

Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.

Crespo RA, Dang Q, Zhou NE, Guthrie LM, Snavely TC, Dong W, Loesch KA, Suzuki T, You L, Wang W, O'Malley T, Parish T, Olsen DB, Sacchettini JC. Crespo RA, et al. J Med Chem. 2019 May 9;62(9):4483-4499. doi: 10.1021/acs.jmedchem.9b00020. Epub 2019 Apr 19. J Med Chem. 2019. PMID: 31002508 Free PMC article.

5

Synthesis and HCV inhibitory properties of 9-deaza- and 7,9-dideaza-7-oxa-2'-C-methyladenosine.

Butora G, Olsen DB, Carroll SS, McMasters DR, Schmitt C, Leone JF, Stahlhut M, Burlein C, Maccoss M. Butora G, et al. Bioorg Med Chem. 2007 Aug 1;15(15):5219-29. doi: 10.1016/j.bmc.2007.05.020. Epub 2007 May 22. Bioorg Med Chem. 2007. PMID: 17521911

6

Nucleoside analog inhibitors of hepatitis C virus replication.

Carroll SS, Olsen DB. Carroll SS, et al. Among authors: olsen db. Infect Disord Drug Targets. 2006 Mar;6(1):17-29. doi: 10.2174/187152606776056698. Infect Disord Drug Targets. 2006. PMID: 16787301 Review.

7

A genotype 2b NS5B polymerase with novel substitutions supports replication of a chimeric HCV 1b:2b replicon containing a genotype 1b NS3-5A background.

Graham DJ, Stahlhut M, Flores O, Olsen DB, Hazuda DJ, Lafemina RL, Ludmerer SW. Graham DJ, et al. Antiviral Res. 2006 Jan;69(1):24-30. doi: 10.1016/j.antiviral.2005.08.005. Epub 2005 Nov 4. Antiviral Res. 2006. PMID: 16297457

8

A transient cell-based phenotype assay for hepatitis C NS3/4A protease: application to potency determinations of a novel macrocyclic inhibitor against diverse protease sequences isolated from plasma infected with HCV.

Ludmerer SW, Graham DJ, Patel M, Gilbert K, Stahlhut M, Olsen DB. Ludmerer SW, et al. J Virol Methods. 2008 Aug;151(2):301-307. doi: 10.1016/j.jviromet.2008.05.014. Epub 2008 Jun 25. J Virol Methods. 2008. PMID: 18582955

9

Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.

Rudd MT, McCauley JA, Romano JJ, Butcher JW, Bush K, McIntyre CJ, Nguyen KT, Gilbert KF, Lyle TA, Holloway MK, Wan BL, Vacca JP, Summa V, Harper S, Rowley M, Carroll SS, Burlein C, DiMuzio JM, Gates A, Graham DJ, Huang Q, Ludmerer SW, McClain S, McHale C, Stahlhut M, Fandozzi C, Taylor A, Trainor N, Olsen DB, Liverton NJ. Rudd MT, et al. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7201-6. doi: 10.1016/j.bmcl.2012.08.106. Epub 2012 Sep 7. Bioorg Med Chem Lett. 2012. PMID: 23021993

10

Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.

Rudd MT, McIntyre CJ, Romano JJ, Butcher JW, Holloway MK, Bush K, Nguyen KT, Gilbert KF, Lyle TA, Liverton NJ, Wan BL, Summa V, Harper S, Rowley M, Vacca JP, Carroll SS, Burlein C, DiMuzio JM, Gates A, Graham DJ, Huang Q, Ludmerer SW, McClain S, McHale C, Stahlhut M, Fandozzi C, Taylor A, Trainor N, Olsen DB, McCauley JA. Rudd MT, et al. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7207-13. doi: 10.1016/j.bmcl.2012.09.061. Epub 2012 Oct 2. Bioorg Med Chem Lett. 2012. PMID: 23084906

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