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Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair.
Harnicek D, Kampmann E, Lauber K, Hennel R, Cardoso Martins AS, Guo Y, Belka C, Mörtl S, Gallmeier E, Kanaar R, Mansmann U, Hucl T, Lindner LH, Hiddemann W, Issels RD. Harnicek D, et al. Among authors: kanaar r. Int J Cancer. 2016 Jul 15;139(2):467-79. doi: 10.1002/ijc.30070. Epub 2016 Mar 25. Int J Cancer. 2016. PMID: 26933761 Free article.
Exploiting DNA repair defects for novel cancer therapies.
van Gent DC, Kanaar R. van Gent DC, et al. Among authors: kanaar r. Mol Biol Cell. 2016 Jul 15;27(14):2145-8. doi: 10.1091/mbc.E15-10-0698. Mol Biol Cell. 2016. PMID: 27418635 Free PMC article.
Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies.
van den Tempel N, Odijk H, van Holthe N, Naipal K, Raams A, Eppink B, van Gent DC, Hardillo J, Verduijn GM, Drooger JC, van Rhoon GC, Smedts DHPM, van Doorn HC, Boormans JL, Jager A, Franckena M, Kanaar R. van den Tempel N, et al. Among authors: kanaar r. Int J Hyperthermia. 2018 Jun;34(4):407-414. doi: 10.1080/02656736.2017.1355487. Epub 2017 Jul 31. Int J Hyperthermia. 2018. PMID: 28705099 Free article.
217 results