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A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury.
Delbary-Gossart S, Lee S, Baroni M, Lamarche I, Arnone M, Canolle B, Lin A, Sacramento J, Salegio EA, Castel MN, Delesque-Touchard N, Alam A, Laboudie P, Ferzaz B, Savi P, Herbert JM, Manley GT, Ferguson AR, Bresnahan JC, Bono F, Beattie MS. Delbary-Gossart S, et al. Among authors: herbert jm. Brain. 2016 Jun;139(Pt 6):1762-82. doi: 10.1093/brain/aww074. Epub 2016 Apr 15. Brain. 2016. PMID: 27084575 Free PMC article.
Heterodimerization with vascular endothelial growth factor receptor-2 (VEGFR-2) is necessary for VEGFR-3 activity.
Alam A, Herault JP, Barron P, Favier B, Fons P, Delesque-Touchard N, Senegas I, Laboudie P, Bonnin J, Cassan C, Savi P, Ruggeri B, Carmeliet P, Bono F, Herbert JM. Alam A, et al. Among authors: herbert jm. Biochem Biophys Res Commun. 2004 Nov 12;324(2):909-15. doi: 10.1016/j.bbrc.2004.08.237. Biochem Biophys Res Commun. 2004. PMID: 15474514
N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist.
Boldron C, Besse A, Bordes MF, Tissandié S, Yvon X, Gau B, Badorc A, Rousseaux T, Barré G, Meneyrol J, Zech G, Nazare M, Fossey V, Pflieger AM, Bonnet-Lignon S, Millet L, Briot C, Dol F, Hérault JP, Savi P, Lassalle G, Delesque N, Herbert JM, Bono F. Boldron C, et al. Among authors: herbert jm. J Med Chem. 2014 Sep 11;57(17):7293-316. doi: 10.1021/jm500588w. Epub 2014 Aug 25. J Med Chem. 2014. PMID: 25075638
Regulator of G-protein signaling 18 controls both platelet generation and function.
Delesque-Touchard N, Pendaries C, Volle-Challier C, Millet L, Salel V, Hervé C, Pflieger AM, Berthou-Soulie L, Prades C, Sorg T, Herbert JM, Savi P, Bono F. Delesque-Touchard N, et al. Among authors: herbert jm. PLoS One. 2014 Nov 18;9(11):e113215. doi: 10.1371/journal.pone.0113215. eCollection 2014. PLoS One. 2014. PMID: 25405900 Free PMC article.
439 results