Hopkins CR - Search Results

1

Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists.

Witt JO, McCollum AL, Hurtado MA, Huseman ED, Jeffries DE, Temple KJ, Plumley HC, Blobaum AL, Lindsley CW, Hopkins CR. Witt JO, et al. Among authors: hopkins cr. Bioorg Med Chem Lett. 2016 May 15;26(10):2481-2488. doi: 10.1016/j.bmcl.2016.03.102. Epub 2016 Mar 30. Bioorg Med Chem Lett. 2016. PMID: 27080176 Free PMC article.

2

Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation.

Hopkins C, Neuenschwander K, Scotese A, Jackson S, Nieduzak T, Pauls H, Liang G, Sides K, Cramer D, Cairns J, Maignan S, Mathieu M. Hopkins C, et al. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4819-23. doi: 10.1016/j.bmcl.2004.07.051. Bioorg Med Chem Lett. 2004. PMID: 15341931

3

Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase.

Hopkins CR, Czekaj M, Kaye SS, Gao Z, Pribish J, Pauls H, Liang G, Sides K, Cramer D, Cairns J, Luo Y, Lim HK, Vaz R, Rebello S, Maignan S, Dupuy A, Mathieu M, Levell J. Hopkins CR, et al. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2734-7. doi: 10.1016/j.bmcl.2005.04.002. Bioorg Med Chem Lett. 2005. PMID: 15911249

4

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.

Hopkins CR, O'neil SV, Laufersweiler MC, Wang Y, Pokross M, Mekel M, Evdokimov A, Walter R, Kontoyianni M, Petrey ME, Sabatakos G, Roesgen JT, Richardson E, Demuth TP Jr. Hopkins CR, et al. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5659-63. doi: 10.1016/j.bmcl.2006.08.003. Epub 2006 Aug 21. Bioorg Med Chem Lett. 2006. PMID: 16919947

5

Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).

Engers DW, Niswender CM, Weaver CD, Jadhav S, Menon UN, Zamorano R, Conn PJ, Lindsley CW, Hopkins CR. Engers DW, et al. Among authors: hopkins cr. J Med Chem. 2009 Jul 23;52(14):4115-8. doi: 10.1021/jm9005065. J Med Chem. 2009. PMID: 19469556 Free PMC article.

6

Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).

Williams R, Johnson KA, Gentry PR, Niswender CM, Weaver CD, Conn PJ, Lindsley CW, Hopkins CR. Williams R, et al. Among authors: hopkins cr. Bioorg Med Chem Lett. 2009 Sep 1;19(17):4967-70. doi: 10.1016/j.bmcl.2009.07.072. Epub 2009 Jul 18. Bioorg Med Chem Lett. 2009. PMID: 19640716 Free PMC article.

7

Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease.

Lindsley CW, Niswender CM, Engers DW, Hopkins CR. Lindsley CW, et al. Among authors: hopkins cr. Curr Top Med Chem. 2009;9(10):949-63. Curr Top Med Chem. 2009. PMID: 19754407 Review.

8

Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

Bridges TM, Kennedy JP, Cho HP, Breininger ML, Gentry PR, Hopkins CR, Conn PJ, Lindsley CW. Bridges TM, et al. Among authors: hopkins cr. Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62. doi: 10.1016/j.bmcl.2009.11.089. Epub 2009 Nov 22. Bioorg Med Chem Lett. 2010. PMID: 20004578 Free PMC article.

9

In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors.

Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, Hopkins CR, Lindsley CW, Hong CC. Hao J, et al. Among authors: hopkins cr. ACS Chem Biol. 2010 Feb 19;5(2):245-53. doi: 10.1021/cb9002865. ACS Chem Biol. 2010. PMID: 20020776 Free PMC article.

10

mGluR4-positive allosteric modulation as potential treatment for Parkinson's disease.

Hopkins CR, Lindsley CW, Niswender CM. Hopkins CR, et al. Future Med Chem. 2009 Jun;1(3):501-13. doi: 10.4155/fmc.09.38. Future Med Chem. 2009. PMID: 20161443 Free PMC article. Review.

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