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Pharmacological targeting of the Hsp70 chaperone.
Patury S, Miyata Y, Gestwicki JE. Patury S, et al. Among authors: gestwicki je. Curr Top Med Chem. 2009;9(15):1337-51. doi: 10.2174/156802609789895674. Curr Top Med Chem. 2009. PMID: 19860737 Free PMC article. Review.
Heat shock protein 70 (hsp70) as an emerging drug target.
Evans CG, Chang L, Gestwicki JE. Evans CG, et al. Among authors: gestwicki je. J Med Chem. 2010 Jun 24;53(12):4585-602. doi: 10.1021/jm100054f. J Med Chem. 2010. PMID: 20334364 Free PMC article. Review. No abstract available.
Allostery in the Hsp70 chaperone proteins.
Zuiderweg ER, Bertelsen EB, Rousaki A, Mayer MP, Gestwicki JE, Ahmad A. Zuiderweg ER, et al. Among authors: gestwicki je. Top Curr Chem. 2013;328:99-153. doi: 10.1007/128_2012_323. Top Curr Chem. 2013. PMID: 22576356 Free PMC article. Review.
Hsp70 protein complexes as drug targets.
Assimon VA, Gillies AT, Rauch JN, Gestwicki JE. Assimon VA, et al. Among authors: gestwicki je. Curr Pharm Des. 2013;19(3):404-17. doi: 10.2174/138161213804143699. Curr Pharm Des. 2013. PMID: 22920901 Free PMC article. Review.
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.
Wang AM, Miyata Y, Klinedinst S, Peng HM, Chua JP, Komiyama T, Li X, Morishima Y, Merry DE, Pratt WB, Osawa Y, Collins CA, Gestwicki JE, Lieberman AP. Wang AM, et al. Among authors: gestwicki je. Nat Chem Biol. 2013 Feb;9(2):112-8. doi: 10.1038/nchembio.1140. Epub 2012 Dec 9. Nat Chem Biol. 2013. PMID: 23222885 Free PMC article.
Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.
Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Miyata Y, et al. Among authors: gestwicki je. ACS Chem Neurosci. 2013 Jun 19;4(6):930-9. doi: 10.1021/cn300210g. Epub 2013 Mar 20. ACS Chem Neurosci. 2013. PMID: 23472668 Free PMC article.
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.
Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA. Abisambra J, et al. Among authors: gestwicki je. Biol Psychiatry. 2013 Sep 1;74(5):367-74. doi: 10.1016/j.biopsych.2013.02.027. Epub 2013 Apr 19. Biol Psychiatry. 2013. PMID: 23607970 Free PMC article.
232 results