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Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4.
Warfield KL, Plummer EM, Sayce AC, Alonzi DS, Tang W, Tyrrell BE, Hill ML, Caputo AT, Killingbeck SS, Beatty PR, Harris E, Iwaki R, Kinami K, Ide D, Kiappes JL, Kato A, Buck MD, King K, Eddy W, Khaliq M, Sampath A, Treston AM, Dwek RA, Enterlein SG, Miller JL, Zitzmann N, Ramstedt U, Shresta S. Warfield KL, et al. Among authors: sampath a. Antiviral Res. 2016 May;129:93-98. doi: 10.1016/j.antiviral.2016.03.001. Epub 2016 Mar 3. Antiviral Res. 2016. PMID: 26946111 Free PMC article.
Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects.
Callahan M, Treston AM, Lin G, Smith M, Kaufman B, Khaliq M, Evans DeWald L, Spurgers K, Warfield KL, Lowe P, Duchars M, Sampath A, Ramstedt U. Callahan M, et al. Among authors: sampath a. PLoS Negl Trop Dis. 2022 Aug 8;16(8):e0010636. doi: 10.1371/journal.pntd.0010636. eCollection 2022 Aug. PLoS Negl Trop Dis. 2022. PMID: 35939501 Free PMC article. Clinical Trial.
Dengue Virus Evolution under a Host-Targeted Antiviral.
Plummer E, Buck MD, Sanchez M, Greenbaum JA, Turner J, Grewal R, Klose B, Sampath A, Warfield KL, Peters B, Ramstedt U, Shresta S. Plummer E, et al. Among authors: sampath a. J Virol. 2015 May;89(10):5592-601. doi: 10.1128/JVI.00028-15. Epub 2015 Mar 11. J Virol. 2015. PMID: 25762732 Free PMC article.
Reproductive and developmental toxicology studies of iminosugar UV-4.
Shearer J, Wolfe G, Khaliq M, Kaufman B, Sampath A, Warfield KL, Ramstedt U, Treston A. Shearer J, et al. Among authors: sampath a. Reprod Toxicol. 2022 Dec;114:9-21. doi: 10.1016/j.reprotox.2022.09.007. Epub 2022 Oct 4. Reprod Toxicol. 2022. PMID: 36206921 Free article.
Dengue Antiviral Development: A Continuing Journey.
Low JG, Gatsinga R, Vasudevan SG, Sampath A. Low JG, et al. Among authors: sampath a. Adv Exp Med Biol. 2018;1062:319-332. doi: 10.1007/978-981-10-8727-1_22. Adv Exp Med Biol. 2018. PMID: 29845542 Review.
161 results