Small molecule inhibits respiratory syncytial virus entry and infection by blocking the interaction of the viral fusion protein with the cell membrane.
Tang W, Li M, Liu Y, Liang N, Yang Z, Zhao Y, Wu S, Lu S, Li Y, Liu F.
Tang W, et al. Among authors: liu y, liu f.
FASEB J. 2019 Mar;33(3):4287-4299. doi: 10.1096/fj.201800579R. Epub 2018 Dec 20.
FASEB J. 2019.
PMID: 30571312
Free PMC article.
We showed for the first time that compound 3,4-DCQAME potently inhibits RSV entry and infection. In vitro, 3,4-DCQAME can interact with F(ecto), the ectodomain of RSV fusion (F) protein. In cultured cells, the compound can block the interaction of F(ecto) pro …
We showed for the first time that compound 3,4-DCQAME potently inhibits RSV entry and infection. In vitro, 3,4-DCQAME can interact with F …