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A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.
Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, Mori H. Tomiyama T, et al. Among authors: klein wl. J Neurosci. 2010 Apr 7;30(14):4845-56. doi: 10.1523/JNEUROSCI.5825-09.2010. J Neurosci. 2010. PMID: 20371804 Free PMC article.
The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells.
Nishitsuji K, Tomiyama T, Ishibashi K, Ito K, Teraoka R, Lambert MP, Klein WL, Mori H. Nishitsuji K, et al. Among authors: klein wl. Am J Pathol. 2009 Mar;174(3):957-69. doi: 10.2353/ajpath.2009.080480. Epub 2009 Jan 22. Am J Pathol. 2009. PMID: 19164507 Free PMC article.
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.
Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, Saido TC, Klein WL, Duff KE, Aisen PS, Matsuoka Y. Hirata-Fukae C, et al. Among authors: klein wl. Brain Res. 2008 Jun 24;1216:92-103. doi: 10.1016/j.brainres.2008.03.079. Epub 2008 Apr 10. Brain Res. 2008. PMID: 18486110
180 results