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Discovery of notch-sparing gamma-secretase inhibitors.
Augelli-Szafran CE, Wei HX, Lu D, Zhang J, Gu Y, Yang T, Osenkowski P, Ye W, Wolfe MS. Augelli-Szafran CE, et al. Among authors: osenkowski p. Curr Alzheimer Res. 2010 May;7(3):207-9. doi: 10.2174/156720510791050920. Curr Alzheimer Res. 2010. PMID: 20088802 Free PMC article. Review.
Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme.
Toth M, Hernandez-Barrantes S, Osenkowski P, Bernardo MM, Gervasi DC, Shimura Y, Meroueh O, Kotra LP, Gálvez BG, Arroyo AG, Mobashery S, Fridman R. Toth M, et al. Among authors: osenkowski p. J Biol Chem. 2002 Jul 19;277(29):26340-50. doi: 10.1074/jbc.M200655200. Epub 2002 May 9. J Biol Chem. 2002. PMID: 12004057 Free article.
The inactive 44-kDa processed form of membrane type 1 matrix metalloproteinase (MT1-MMP) enhances proteolytic activity via regulation of endocytosis of active MT1-MMP.
Cho JA, Osenkowski P, Zhao H, Kim S, Toth M, Cole K, Aboukameel A, Saliganan A, Schuger L, Bonfil RD, Fridman R. Cho JA, et al. Among authors: osenkowski p. J Biol Chem. 2008 Jun 20;283(25):17391-405. doi: 10.1074/jbc.M708943200. Epub 2008 Apr 15. J Biol Chem. 2008. PMID: 18413312 Free PMC article.
19 results