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Tetrodotoxin-sensitive α-subunits of voltage-gated sodium channels are relevant for inhibition of cardiac sodium currents by local anesthetics.
Stoetzer C, Doll T, Stueber T, Herzog C, Echtermeyer F, Greulich F, Rudat C, Kispert A, Wegner F, Leffler A. Stoetzer C, et al. Among authors: leffler a. Naunyn Schmiedebergs Arch Pharmacol. 2016 Jun;389(6):625-36. doi: 10.1007/s00210-016-1231-9. Epub 2016 Mar 22. Naunyn Schmiedebergs Arch Pharmacol. 2016. PMID: 27000037
Optimized preoperative fasting times decrease ketone body concentration and stabilize mean arterial blood pressure during induction of anesthesia in children younger than 36 months: a prospective observational cohort study.
Dennhardt N, Beck C, Huber D, Sander B, Boehne M, Boethig D, Leffler A, Sümpelmann R. Dennhardt N, et al. Among authors: leffler a. Paediatr Anaesth. 2016 Aug;26(8):838-43. doi: 10.1111/pan.12943. Epub 2016 Jun 13. Paediatr Anaesth. 2016. PMID: 27291355
Sodium Channel Nav1.3 Is Expressed by Polymorphonuclear Neutrophils during Mouse Heart and Kidney Ischemia In Vivo and Regulates Adhesion, Transmigration, and Chemotaxis of Human and Mouse Neutrophils In Vitro.
Poffers M, Bühne N, Herzog C, Thorenz A, Chen R, Güler F, Hage A, Leffler A, Echtermeyer F. Poffers M, et al. Among authors: leffler a. Anesthesiology. 2018 Jun;128(6):1151-1166. doi: 10.1097/ALN.0000000000002135. Anesthesiology. 2018. PMID: 29509584 Free article.
Acetaminophen-induced liver injury is mediated by the ion channel TRPV4.
Echtermeyer F, Eberhardt M, Risser L, Herzog C, Gueler F, Khalil M, Engel M, Vondran F, Leffler A. Echtermeyer F, et al. Among authors: leffler a. FASEB J. 2019 Sep;33(9):10257-10268. doi: 10.1096/fj.201802233R. Epub 2019 Jun 17. FASEB J. 2019. PMID: 31207191
Both pharmacological inhibition and genetic deletion of TRPV4 ameliorate APAP-induced necrosis in mouse and human hepatocytes in vitro. Liver injury caused by a systemic overdose of APAP is reduced in TRPV4-deficient mice and in wild-type mice treated with a TRPV4 i …
Both pharmacological inhibition and genetic deletion of TRPV4 ameliorate APAP-induced necrosis in mouse and human hepatocytes in vitro. Live …
Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2.
Fricke TC, Echtermeyer F, Zielke J, de la Roche J, Filipovic MR, Claverol S, Herzog C, Tominaga M, Pumroy RA, Moiseenkova-Bell VY, Zygmunt PM, Leffler A, Eberhardt MJ. Fricke TC, et al. Among authors: leffler a. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24359-24365. doi: 10.1073/pnas.1904332116. Epub 2019 Nov 12. Proc Natl Acad Sci U S A. 2019. PMID: 31719194 Free PMC article.
184 results