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Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC.
Al-Qusairi L, Basquin D, Roy A, Stifanelli M, Rajaram RD, Debonneville A, Nita I, Maillard M, Loffing J, Subramanya AR, Staub O. Al-Qusairi L, et al. Among authors: loffing j. Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F330-42. doi: 10.1152/ajprenal.00002.2016. Epub 2016 Mar 23. Am J Physiol Renal Physiol. 2016. PMID: 27009335 Free PMC article.
Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells.
Flores SY, Loffing-Cueni D, Kamynina E, Daidié D, Gerbex C, Chabanel S, Dudler J, Loffing J, Staub O. Flores SY, et al. Among authors: loffing cueni d, loffing j. J Am Soc Nephrol. 2005 Aug;16(8):2279-87. doi: 10.1681/ASN.2004100828. Epub 2005 Jun 15. J Am Soc Nephrol. 2005. PMID: 15958725
Sgk kinases and their role in epithelial transport.
Loffing J, Flores SY, Staub O. Loffing J, et al. Annu Rev Physiol. 2006;68:461-90. doi: 10.1146/annurev.physiol.68.040104.131654. Annu Rev Physiol. 2006. PMID: 16460280 Review.
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension.
Ronzaud C, Loffing-Cueni D, Hausel P, Debonneville A, Malsure SR, Fowler-Jaeger N, Boase NA, Perrier R, Maillard M, Yang B, Stokes JB, Koesters R, Kumar S, Hummler E, Loffing J, Staub O. Ronzaud C, et al. Among authors: loffing cueni d, loffing j. J Clin Invest. 2013 Feb;123(2):657-65. doi: 10.1172/JCI61110. Epub 2013 Jan 25. J Clin Invest. 2013. PMID: 23348737 Free PMC article.
152 results