Moraca F - Search Results

1

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi.

Ortiz C, Moraca F, Medeiros A, Botta M, Hamilton N, Comini MA. Ortiz C, et al. Among authors: moraca f. Molecules. 2016 Mar 17;21(3):368. doi: 10.3390/molecules21030368. Molecules. 2016. PMID: 26999093 Free PMC article.

2

Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei.

Ortíz C, Moraca F, Laverriere M, Jordan A, Hamilton N, Comini MA. Ortíz C, et al. Among authors: moraca f. Molecules. 2021 Jan 12;26(2):358. doi: 10.3390/molecules26020358. Molecules. 2021. PMID: 33445584 Free PMC article.

3

A fast virtual screening approach to identify structurally diverse inhibitors of trypanothione reductase.

Maccari G, Jaeger T, Moraca F, Biava M, Flohé L, Botta M. Maccari G, et al. Among authors: moraca f. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5255-8. doi: 10.1016/j.bmcl.2011.07.036. Epub 2011 Jul 19. Bioorg Med Chem Lett. 2011. PMID: 21807515

4

Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor.

Mori M, Moraca F, Deodato D, Ferraris DM, Selchow P, Sander P, Rizzi M, Botta M. Mori M, et al. Among authors: moraca f. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2508-11. doi: 10.1016/j.bmcl.2014.04.004. Epub 2014 Apr 13. Bioorg Med Chem Lett. 2014. PMID: 24767848

5

Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography.

Baiocco P, Poce G, Alfonso S, Cocozza M, Porretta GC, Colotti G, Biava M, Moraca F, Botta M, Yardley V, Fiorillo A, Lantella A, Malatesta F, Ilari A. Baiocco P, et al. Among authors: moraca f. ChemMedChem. 2013 Jul;8(7):1175-83. doi: 10.1002/cmdc.201300176. Epub 2013 Jun 3. ChemMedChem. 2013. PMID: 23733388

6

Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors.

Moraca F, De Vita D, Pandolfi F, Di Santo R, Costi R, Cirilli R, D'Auria FD, Panella S, Palamara AT, Simonetti G, Botta M, Scipione L. Moraca F, et al. Eur J Med Chem. 2014 Aug 18;83:665-73. doi: 10.1016/j.ejmech.2014.07.001. Epub 2014 Jul 1. Eur J Med Chem. 2014. PMID: 25010937

7

In vitro screening of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives as antiprotozoal agents and docking studies on Trypanosoma cruzi CYP51.

De Vita D, Moraca F, Zamperini C, Pandolfi F, Di Santo R, Matheeussen A, Maes L, Tortorella S, Scipione L. De Vita D, et al. Among authors: moraca f. Eur J Med Chem. 2016 May 4;113:28-33. doi: 10.1016/j.ejmech.2016.02.028. Epub 2016 Feb 15. Eur J Med Chem. 2016. PMID: 26922226

8

New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.

Friggeri L, Scipione L, Costi R, Kaiser M, Moraca F, Zamperini C, Botta B, Di Santo R, De Vita D, Brun R, Tortorella S. Friggeri L, et al. Among authors: moraca f. ACS Med Chem Lett. 2013 May 7;4(6):538-41. doi: 10.1021/ml400039r. eCollection 2013 Jun 13. ACS Med Chem Lett. 2013. PMID: 24900706 Free PMC article.

9

Application of Free Energy Perturbation (FEP+) to Understanding Ligand Selectivity: A Case Study to Assess Selectivity Between Pairs of Phosphodiesterases (PDE's).

Moraca F, Negri A, de Oliveira C, Abel R. Moraca F, et al. J Chem Inf Model. 2019 Jun 24;59(6):2729-2740. doi: 10.1021/acs.jcim.9b00106. Epub 2019 Jun 12. J Chem Inf Model. 2019. PMID: 31144815

10

Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.

Zhang H, Hsu HC, Kahne SC, Hara R, Zhan W, Jiang X, Burns-Huang K, Ouellette T, Imaeda T, Okamoto R, Kawasaki M, Michino M, Wong TT, Toita A, Yukawa T, Moraca F, Vendome J, Saha P, Sato K, Aso K, Ginn J, Meinke PT, Foley M, Nathan CF, Darwin KH, Li H, Lin G. Zhang H, et al. Among authors: moraca f. J Med Chem. 2021 May 13;64(9):6262-6272. doi: 10.1021/acs.jmedchem.1c00296. Epub 2021 May 5. J Med Chem. 2021. PMID: 33949190 Free PMC article.

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