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A quinone mediator drives oxidations catalysed by alcohol dehydrogenase-containing cell lysates.
Chem Commun (Camb). 2016 Apr 14;52(29):5198-201. doi: 10.1039/c5cc10316a. Epub 2016 Mar 21.
Chem Commun (Camb). 2016.
PMID: 26998531
Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation.
Schulz-Fincke J, Hau M, Barth J, Robaa D, Willmann D, Kürner A, Haas J, Greve G, Haydn T, Fulda S, Lübbert M, Lüdeke S, Berg T, Sippl W, Schüle R, Jung M.
Schulz-Fincke J, et al.
Eur J Med Chem. 2018 Jan 20;144:52-67. doi: 10.1016/j.ejmech.2017.12.001. Epub 2017 Dec 6.
Eur J Med Chem. 2018.
PMID: 29247860
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Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity.
Schmitt ML, Hauser AT, Carlino L, Pippel M, Schulz-Fincke J, Metzger E, Willmann D, Yiu T, Barton M, Schüle R, Sippl W, Jung M.
Schmitt ML, et al. Among authors: schulz fincke j.
J Med Chem. 2013 Sep 26;56(18):7334-42. doi: 10.1021/jm400792m. Epub 2013 Sep 5.
J Med Chem. 2013.
PMID: 24007511
Free PMC article.
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Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate.
Schmitt ML, Ladwein KI, Carlino L, Schulz-Fincke J, Willmann D, Metzger E, Schilcher P, Imhof A, Schüle R, Sippl W, Jung M.
Schmitt ML, et al. Among authors: schulz fincke j.
J Biomol Screen. 2014 Jul;19(6):973-8. doi: 10.1177/1087057114529156. Epub 2014 Mar 31.
J Biomol Screen. 2014.
PMID: 24687155
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Correction: LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML.
Barth J, Abou-El-Ardat K, Dalic D, Kurrle N, Maier AM, Mohr S, Schütte J, Vassen L, Greve G, Schulz-Fincke J, Schmitt M, Tosic M, Metzger E, Bug G, Khandanpour C, Wagner SA, Lübbert M, Jung M, Serve H, Schüle R, Berg T.
Barth J, et al. Among authors: schulz fincke j.
Leukemia. 2019 Jun;33(6):1541. doi: 10.1038/s41375-019-0415-y.
Leukemia. 2019.
PMID: 30837671
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LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML.
Barth J, Abou-El-Ardat K, Dalic D, Kurrle N, Maier AM, Mohr S, Schütte J, Vassen L, Greve G, Schulz-Fincke J, Schmitt M, Tosic M, Metzger E, Bug G, Khandanpour C, Wagner SA, Lübbert M, Jung M, Serve H, Schüle R, Berg T.
Barth J, et al. Among authors: schulz fincke j.
Leukemia. 2019 Jun;33(6):1411-1426. doi: 10.1038/s41375-018-0375-7. Epub 2019 Jan 24.
Leukemia. 2019.
PMID: 30679800
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