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Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.
Meijer L, Nelson DJ, Riazanski V, Gabdoulkhakova AG, Hery-Arnaud G, Le Berre R, Loaëc N, Oumata N, Galons H, Nowak E, Gueganton L, Dorothée G, Prochazkova M, Hall B, Kulkarni AB, Gray RD, Rossi AG, Witko-Sarsat V, Norez C, Becq F, Ravel D, Mottier D, Rault G. Meijer L, et al. Among authors: galons h. J Innate Immun. 2016;8(4):330-49. doi: 10.1159/000444256. Epub 2016 Mar 18. J Innate Immun. 2016. PMID: 26987072 Free PMC article. Review.
TRPC6 channel translocation into phagosomal membrane augments phagosomal function.
Riazanski V, Gabdoulkhakova AG, Boynton LS, Eguchi RR, Deriy LV, Hogarth DK, Loaëc N, Oumata N, Galons H, Brown ME, Shevchenko P, Gallan AJ, Yoo SG, Naren AP, Villereal ML, Beacham DW, Bindokas VP, Birnbaumer L, Meijer L, Nelson DJ. Riazanski V, et al. Among authors: galons h. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6486-95. doi: 10.1073/pnas.1518966112. Epub 2015 Nov 10. Proc Natl Acad Sci U S A. 2015. PMID: 26604306 Free PMC article.
A Simple Isomerization of the Purine Scaffold of a Kinase Inhibitor, Roscovitine, Affords a Four- to Seven-Fold Enhancement of Its Affinity for Four CDKs. Could This Be Traced Back to Conjugation-Induced Stiffenings/Loosenings of Rotational Barriers?
El Hage K, Piquemal JP, Oumata N, Meijer L, Galons H, Gresh N. El Hage K, et al. Among authors: galons h. ACS Omega. 2017 Jul 31;2(7):3467-3474. doi: 10.1021/acsomega.7b00471. Epub 2017 Jul 12. ACS Omega. 2017. PMID: 30023695 Free PMC article.
CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.
Delehouzé C, Godl K, Loaëc N, Bruyère C, Desban N, Oumata N, Galons H, Roumeliotis TI, Giannopoulou EG, Grenet J, Twitchell D, Lahti J, Mouchet N, Galibert MD, Garbis SD, Meijer L. Delehouzé C, et al. Among authors: galons h. Oncogene. 2014 Dec 11;33(50):5675-87. doi: 10.1038/onc.2013.513. Epub 2013 Dec 9. Oncogene. 2014. PMID: 24317512 Free PMC article.
Cyclin-dependent kinase inhibitors closer to market launch?
Galons H, Oumata N, Gloulou O, Meijer L. Galons H, et al. Expert Opin Ther Pat. 2013 Aug;23(8):945-63. doi: 10.1517/13543776.2013.789861. Epub 2013 Apr 22. Expert Opin Ther Pat. 2013. PMID: 23600454 Review.
101 results