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A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.
Massignan T, Cimini S, Stincardini C, Cerovic M, Vanni I, Elezgarai SR, Moreno J, Stravalaci M, Negro A, Sangiovanni V, Restelli E, Riccardi G, Gobbi M, Castilla J, Borsello T, Nonno R, Biasini E. Massignan T, et al. Among authors: castilla j. Sci Rep. 2016 Mar 15;6:23180. doi: 10.1038/srep23180. Sci Rep. 2016. PMID: 26976106 Free PMC article.
Animal models for testing anti-prion drugs.
Fernández-Borges N, Elezgarai SR, Eraña H, Castilla J. Fernández-Borges N, et al. Among authors: castilla j. Curr Top Med Chem. 2013;13(19):2504-21. doi: 10.2174/15680266113136660177. Curr Top Med Chem. 2013. PMID: 24059334 Review.
Recombinant human prion protein inhibits prion propagation in vitro.
Yuan J, Zhan YA, Abskharon R, Xiao X, Martinez MC, Zhou X, Kneale G, Mikol J, Lehmann S, Surewicz WK, Castilla J, Steyaert J, Zhang S, Kong Q, Petersen RB, Wohlkonig A, Zou WQ. Yuan J, et al. Among authors: castilla j. Sci Rep. 2013 Oct 9;3:2911. doi: 10.1038/srep02911. Sci Rep. 2013. PMID: 24105336 Free PMC article.
Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease.
Bouybayoune I, Mantovani S, Del Gallo F, Bertani I, Restelli E, Comerio L, Tapella L, Baracchi F, Fernández-Borges N, Mangieri M, Bisighini C, Beznoussenko GV, Paladini A, Balducci C, Micotti E, Forloni G, Castilla J, Fiordaliso F, Tagliavini F, Imeri L, Chiesa R. Bouybayoune I, et al. Among authors: castilla j. PLoS Pathog. 2015 Apr 16;11(4):e1004796. doi: 10.1371/journal.ppat.1004796. eCollection 2015 Apr. PLoS Pathog. 2015. PMID: 25880443 Free PMC article.
Animal models for prion-like diseases.
Fernández-Borges N, Eraña H, Venegas V, Elezgarai SR, Harrathi C, Castilla J. Fernández-Borges N, et al. Among authors: castilla j. Virus Res. 2015 Sep 2;207:5-24. doi: 10.1016/j.virusres.2015.04.014. Epub 2015 Apr 20. Virus Res. 2015. PMID: 25907990 Review.
690 results