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Synthesis, in vitro evaluation, and molecular modeling investigation of benzenesulfonimide peroxisome proliferator-activated receptors α antagonists.
Ammazzalorso A, Carrieri A, Verginelli F, Bruno I, Carbonara G, D'Angelo A, De Filippis B, Fantacuzzi M, Florio R, Fracchiolla G, Giampietro L, Giancristofaro A, Maccallini C, Cama A, Amoroso R. Ammazzalorso A, et al. Among authors: fracchiolla g. Eur J Med Chem. 2016 May 23;114:191-200. doi: 10.1016/j.ejmech.2016.02.064. Epub 2016 Feb 27. Eur J Med Chem. 2016. PMID: 26974385
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of an aryloxyalkyl group alpha to the carboxylic function of 4-chloro-phenoxyacetic acid.
Carbonara G, Fracchiolla G, Loiodice F, Tortorella P, Conte-Camerino D, De Luca A, Liantonio A. Carbonara G, et al. Among authors: fracchiolla g. Farmaco. 2001 Oct;56(10):749-54. doi: 10.1016/s0014-827x(01)01127-2. Farmaco. 2001. PMID: 11718267
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid.
Liantonio A, Accardi A, Carbonara G, Fracchiolla G, Loiodice F, Tortorella P, Traverso S, Guida P, Pierno S, De Luca A, Camerino DC, Pusch M. Liantonio A, et al. Among authors: fracchiolla g. Mol Pharmacol. 2002 Aug;62(2):265-71. doi: 10.1124/mol.62.2.265. Mol Pharmacol. 2002. PMID: 12130677
Activation and inhibition of kidney CLC-K chloride channels by fenamates.
Liantonio A, Picollo A, Babini E, Carbonara G, Fracchiolla G, Loiodice F, Tortorella V, Pusch M, Camerino DC. Liantonio A, et al. Among authors: fracchiolla g. Mol Pharmacol. 2006 Jan;69(1):165-73. doi: 10.1124/mol.105.017384. Epub 2005 Oct 21. Mol Pharmacol. 2006. PMID: 16244177
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: a docking and molecular dynamics study.
Lavecchia A, Cosconati S, Novellino E, Calleri E, Temporini C, Massolini G, Carbonara G, Fracchiolla G, Loiodice F. Lavecchia A, et al. Among authors: fracchiolla g. J Mol Graph Model. 2007 Mar;25(6):773-83. doi: 10.1016/j.jmgm.2006.07.001. Epub 2006 Aug 8. J Mol Graph Model. 2007. PMID: 16901739
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity.
Temporini C, Calleri E, Fracchiolla G, Carbonara G, Loiodice F, Lavecchia A, Tortorella P, Brusotti G, Massolini G. Temporini C, et al. Among authors: fracchiolla g. J Pharm Biomed Anal. 2007 Oct 18;45(2):211-8. doi: 10.1016/j.jpba.2007.06.005. Epub 2007 Jun 12. J Pharm Biomed Anal. 2007. PMID: 17629437
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