Reduced mitochondrial activity in colonocytes facilitates AMPKα2-dependent inflammation.
Heller S, Penrose HM, Cable C, Biswas D, Nakhoul H, Baddoo M, Flemington E, Crawford SE, Savkovic SD.
Heller S, et al. Among authors: cable c.
FASEB J. 2017 May;31(5):2013-2025. doi: 10.1096/fj.201600976R. Epub 2017 Feb 9.
FASEB J. 2017.
PMID: 28183804
Free PMC article.
In the inflamed colon of humans and mice, we found decreased levels of mitochondrial complex cytochrome c oxidase I/IV and lower ATP levels. Thus, we generated colonic rho(0) cells with reduced mitochondrial function linked to ATP production by selective depletion of mitoc …
In the inflamed colon of humans and mice, we found decreased levels of mitochondrial complex cytochrome c oxidase I/IV and lower ATP …