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Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.
Heimburg T, Chakrabarti A, Lancelot J, Marek M, Melesina J, Hauser AT, Shaik TB, Duclaud S, Robaa D, Erdmann F, Schmidt M, Romier C, Pierce RJ, Jung M, Sippl W. Heimburg T, et al. Among authors: pierce rj. J Med Chem. 2016 Mar 24;59(6):2423-35. doi: 10.1021/acs.jmedchem.5b01478. Epub 2016 Mar 14. J Med Chem. 2016. PMID: 26937828 Free article.
Vaccine strategies against schistosomiasis.
Capron A, Dessaint JP, Capron M, Pierce RJ. Capron A, et al. Among authors: pierce rj. Mem Inst Oswaldo Cruz. 1992;87 Suppl 5:1-9. doi: 10.1590/s0074-02761992000900001. Mem Inst Oswaldo Cruz. 1992. PMID: 1342702 Free article. Review.
Expression of a Schistosoma mansoni 28-kilodalton glutathione S-transferase in the livers of transgenic mice and its effect on parasite infection.
Xu X, Lemaire C, Grzych JM, Pierce RJ, Raccurt M, Mullier F, Zerimech F, Decavel JP, Peyrol S, Liu J, Fontaine J, Lafitte S, Capron A, Cesbron JY. Xu X, et al. Among authors: pierce rj. Infect Immun. 1997 Sep;65(9):3867-74. doi: 10.1128/iai.65.9.3867-3874.1997. Infect Immun. 1997. PMID: 9284165 Free PMC article.
Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni.
Marek M, Kannan S, Hauser AT, Moraes Mourão M, Caby S, Cura V, Stolfa DA, Schmidtkunz K, Lancelot J, Andrade L, Renaud JP, Oliveira G, Sippl W, Jung M, Cavarelli J, Pierce RJ, Romier C. Marek M, et al. Among authors: pierce rj. PLoS Pathog. 2013;9(9):e1003645. doi: 10.1371/journal.ppat.1003645. Epub 2013 Sep 26. PLoS Pathog. 2013. PMID: 24086136 Free PMC article.
Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.
Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M. Stolfa DA, et al. Among authors: pierce rj. J Mol Biol. 2014 Oct 9;426(20):3442-53. doi: 10.1016/j.jmb.2014.03.007. Epub 2014 Mar 20. J Mol Biol. 2014. PMID: 24657767 Free article.
219 results