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N-ω-chloroacetyl-L-ornithine has in-vitro activity against cancer cell lines and in-vivo activity against ascitic and solid tumors.
Anticancer Drugs. 2016 Jul;27(6):508-18. doi: 10.1097/CAD.0000000000000353.
Anticancer Drugs. 2016.
PMID: 26918391
N-ω-chloroacetyl-l-ornithine, a new competitive inhibitor of ornithine decarboxylase, induces selective growth inhibition and cytotoxicity on human cancer cells versus normal cells.
Medina-Enríquez MM, Alcántara-Farfán V, Aguilar-Faisal L, Trujillo-Ferrara JG, Rodríguez-Páez L, Vargas-Ramírez AL.
Medina-Enríquez MM, et al.
J Enzyme Inhib Med Chem. 2015 Jun;30(3):345-53. doi: 10.3109/14756366.2014.926342. Epub 2014 Jun 18.
J Enzyme Inhib Med Chem. 2015.
PMID: 24939101
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ACE2: the molecular doorway to SARS-CoV-2.
Medina-Enríquez MM, Lopez-León S, Carlos-Escalante JA, Aponte-Torres Z, Cuapio A, Wegman-Ostrosky T.
Medina-Enríquez MM, et al.
Cell Biosci. 2020 Dec 30;10(1):148. doi: 10.1186/s13578-020-00519-8.
Cell Biosci. 2020.
PMID: 33380340
Free PMC article.
Review.
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Silencing PD-1 and PD-L1: the potential of PolyPurine Reverse Hoogsteen hairpins for the elimination of tumor cells.
Ciudad CJ, Medina Enriquez MM, Félix AJ, Bener G, Noé V.
Ciudad CJ, et al. Among authors: medina enriquez mm.
Immunotherapy. 2019 Apr;11(5):369-372. doi: 10.2217/imt-2018-0215.
Immunotherapy. 2019.
PMID: 30786843
Review.
No abstract available.
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Cancer immunotherapy using PolyPurine Reverse Hoogsteen hairpins targeting the PD-1/PD-L1 pathway in human tumor cells.
Medina Enríquez MM, Félix AJ, Ciudad CJ, Noé V.
Medina Enríquez MM, et al.
PLoS One. 2018 Nov 6;13(11):e0206818. doi: 10.1371/journal.pone.0206818. eCollection 2018.
PLoS One. 2018.
PMID: 30399174
Free PMC article.
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