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Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer.
Birge RB, Boeltz S, Kumar S, Carlson J, Wanderley J, Calianese D, Barcinski M, Brekken RA, Huang X, Hutchins JT, Freimark B, Empig C, Mercer J, Schroit AJ, Schett G, Herrmann M. Birge RB, et al. Among authors: hutchins jt. Cell Death Differ. 2016 Jun;23(6):962-78. doi: 10.1038/cdd.2016.11. Epub 2016 Feb 26. Cell Death Differ. 2016. PMID: 26915293 Free PMC article. Review.
Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression.
Kasikara C, Kumar S, Kimani S, Tsou WI, Geng K, Davra V, Sriram G, Devoe C, Nguyen KN, Antes A, Krantz A, Rymarczyk G, Wilczynski A, Empig C, Freimark B, Gray M, Schlunegger K, Hutchins J, Kotenko SV, Birge RB. Kasikara C, et al. Mol Cancer Res. 2017 Jun;15(6):753-764. doi: 10.1158/1541-7786.MCR-16-0350. Epub 2017 Feb 9. Mol Cancer Res. 2017. PMID: 28184013 Free PMC article.
Phosphatidylserine-targeting antibodies augment the anti-tumorigenic activity of anti-PD-1 therapy by enhancing immune activation and downregulating pro-oncogenic factors induced by T-cell checkpoint inhibition in murine triple-negative breast cancers.
Gray MJ, Gong J, Hatch MM, Nguyen V, Hughes CC, Hutchins JT, Freimark BD. Gray MJ, et al. Among authors: hutchins jt. Breast Cancer Res. 2016 May 11;18(1):50. doi: 10.1186/s13058-016-0708-2. Breast Cancer Res. 2016. PMID: 27169467 Free PMC article.
The chicken junD gene and its product.
Hartl M, Hutchins JT, Vogt PK. Hartl M, et al. Among authors: hutchins jt. Oncogene. 1991 Sep;6(9):1623-31. Oncogene. 1991. PMID: 1923529
Carbohydrate structure in tumor immunity.
Reading CL, Hutchins JT. Reading CL, et al. Among authors: hutchins jt. Cancer Metastasis Rev. 1985;4(3):221-60. doi: 10.1007/BF00048097. Cancer Metastasis Rev. 1985. PMID: 3935311 Review.
31 results