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Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair.
Croglio MP, Haake JM, Ryan CP, Wang VS, Lapier J, Schlarbaum JP, Dayani Y, Artuso E, Prandi C, Koltai H, Agama K, Pommier Y, Chen Y, Tricoli L, LaRocque JR, Albanese C, Yarden RI. Croglio MP, et al. Among authors: koltai h. Oncotarget. 2016 Mar 22;7(12):13984-4001. doi: 10.18632/oncotarget.7414. Oncotarget. 2016. PMID: 26910887 Free PMC article.
Light is a positive regulator of strigolactone levels in tomato roots.
Koltai H, Cohen M, Chesin O, Mayzlish-Gati E, Bécard G, Puech V, Ben Dor B, Resnick N, Wininger S, Kapulnik Y. Koltai H, et al. J Plant Physiol. 2011 Nov 1;168(16):1993-6. doi: 10.1016/j.jplph.2011.05.022. Epub 2011 Jul 28. J Plant Physiol. 2011. PMID: 21802170
Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells.
Pollock CB, McDonough S, Wang VS, Lee H, Ringer L, Li X, Prandi C, Lee RJ, Feldman AS, Koltai H, Kapulnik Y, Rodriguez OC, Schlegel R, Albanese C, Yarden RI. Pollock CB, et al. Among authors: koltai h. Oncotarget. 2014 Mar 30;5(6):1683-98. doi: 10.18632/oncotarget.1849. Oncotarget. 2014. PMID: 24742967 Free PMC article.
Arabidopsis response to low-phosphate conditions includes active changes in actin filaments and PIN2 polarization and is dependent on strigolactone signalling.
Kumar M, Pandya-Kumar N, Dam A, Haor H, Mayzlish-Gati E, Belausov E, Wininger S, Abu-Abied M, McErlean CS, Bromhead LJ, Prandi C, Kapulnik Y, Koltai H. Kumar M, et al. Among authors: koltai h. J Exp Bot. 2015 Mar;66(5):1499-510. doi: 10.1093/jxb/eru513. Epub 2015 Jan 21. J Exp Bot. 2015. PMID: 25609825 Free PMC article.
Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model.
Mayzlish-Gati E, Laufer D, Grivas CF, Shaknof J, Sananes A, Bier A, Ben-Harosh S, Belausov E, Johnson MD, Artuso E, Levi O, Genin O, Prandi C, Khalaila I, Pines M, Yarden RI, Kapulnik Y, Koltai H. Mayzlish-Gati E, et al. Among authors: koltai h. Cancer Biol Ther. 2015;16(11):1682-8. doi: 10.1080/15384047.2015.1070982. Epub 2015 Jul 20. Cancer Biol Ther. 2015. PMID: 26192476 Free PMC article.
85 results