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Designing proteins to combat disease: Cardiac troponin C as an example.
Davis JP, Shettigar V, Tikunova SB, Little SC, Liu B, Siddiqui JK, Janssen PM, Ziolo MT, Walton SD. Davis JP, et al. Among authors: little sc. Arch Biochem Biophys. 2016 Jul 1;601:4-10. doi: 10.1016/j.abb.2016.02.007. Epub 2016 Feb 18. Arch Biochem Biophys. 2016. PMID: 26901433 Free PMC article. Review.
Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease.
Shettigar V, Zhang B, Little SC, Salhi HE, Hansen BJ, Li N, Zhang J, Roof SR, Ho HT, Brunello L, Lerch JK, Weisleder N, Fedorov VV, Accornero F, Rafael-Fortney JA, Gyorke S, Janssen PM, Biesiadecki BJ, Ziolo MT, Davis JP. Shettigar V, et al. Among authors: little sc. Nat Commun. 2016 Feb 24;7:10794. doi: 10.1038/ncomms10794. Nat Commun. 2016. PMID: 26908229 Free PMC article.
NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model.
Peterson JM, Wang DJ, Shettigar V, Roof SR, Canan BD, Bakkar N, Shintaku J, Gu JM, Little SC, Ratnam NM, Londhe P, Lu L, Gaw CE, Petrosino JM, Liyanarachchi S, Wang H, Janssen PML, Davis JP, Ziolo MT, Sharma SM, Guttridge DC. Peterson JM, et al. Among authors: little sc. Nat Commun. 2018 Aug 24;9(1):3431. doi: 10.1038/s41467-018-05910-1. Nat Commun. 2018. PMID: 30143619 Free PMC article.
Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure.
Makara MA, Curran J, Lubbers ER, Murphy NP, Little SC, Musa H, Smith SA, Unudurthi SD, Rajaram MVS, Janssen PML, Boyden PA, Bradley EA, Hund TJ, Mohler PJ. Makara MA, et al. Among authors: little sc. JACC Basic Transl Sci. 2018 Nov 12;3(5):675-689. doi: 10.1016/j.jacbts.2018.07.008. eCollection 2018 Oct. JACC Basic Transl Sci. 2018. PMID: 30456339 Free PMC article.
99 results