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A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules.
Lim D, Zhou Q, Cox KJ, Law BK, Lee M, Kokkonda P, Sreekanth V, Pergu R, Chaudhary SK, Gangopadhyay SA, Maji B, Lai S, Amako Y, Thompson DB, Subramanian HKK, Mesleh MF, Dančík V, Clemons PA, Wagner BK, Woo CM, Church GM, Choudhary A. Lim D, et al. Among authors: cox kj. Nat Cell Biol. 2022 Dec;24(12):1766-1775. doi: 10.1038/s41556-022-01005-8. Epub 2022 Nov 17. Nat Cell Biol. 2022. PMID: 36396978 Free PMC article.
Precision Control of CRISPR-Cas9 Using Small Molecules and Light.
Gangopadhyay SA, Cox KJ, Manna D, Lim D, Maji B, Zhou Q, Choudhary A. Gangopadhyay SA, et al. Among authors: cox kj. Biochemistry. 2019 Jan 29;58(4):234-244. doi: 10.1021/acs.biochem.8b01202. Epub 2019 Jan 22. Biochemistry. 2019. PMID: 30640437 Free PMC article. Review.
A Singular System with Precise Dosing and Spatiotemporal Control of CRISPR-Cas9.
Manna D, Maji B, Gangopadhyay SA, Cox KJ, Zhou Q, Law BK, Mazitschek R, Choudhary A. Manna D, et al. Among authors: cox kj. Angew Chem Int Ed Engl. 2019 May 6;58(19):6285-6289. doi: 10.1002/anie.201900788. Epub 2019 Apr 2. Angew Chem Int Ed Engl. 2019. PMID: 30834641 Free PMC article.
Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives.
López Del Amo V, Leger BS, Cox KJ, Gill S, Bishop AL, Scanlon GD, Walker JA, Gantz VM, Choudhary A. López Del Amo V, et al. Among authors: cox kj. Cell Rep. 2020 Jun 30;31(13):107841. doi: 10.1016/j.celrep.2020.107841. Cell Rep. 2020. PMID: 32610142 Free PMC article.
61 results