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A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A.
Zeybel M, Luli S, Sabater L, Hardy T, Oakley F, Leslie J, Page A, Moran Salvador E, Sharkey V, Tsukamoto H, Chu DCK, Singh US, Ponzoni M, Perri P, Di Paolo D, Mendivil EJ, Mann J, Mann DA. Zeybel M, et al. Among authors: leslie j. Mol Ther. 2017 Jan 4;25(1):218-231. doi: 10.1016/j.ymthe.2016.10.004. Epub 2017 Jan 4. Mol Ther. 2017. PMID: 28129116 Free PMC article.
A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision-Cut Liver Slices.
Paish HL, Reed LH, Brown H, Bryan MC, Govaere O, Leslie J, Barksby BS, Garcia Macia M, Watson A, Xu X, Zaki MYW, Greaves L, Whitehall J, French J, White SA, Manas DM, Robinson SM, Spoletini G, Griffiths C, Mann DA, Borthwick LA, Drinnan MJ, Mann J, Oakley F. Paish HL, et al. Among authors: leslie j. Hepatology. 2019 Oct;70(4):1377-1391. doi: 10.1002/hep.30651. Epub 2019 May 28. Hepatology. 2019. PMID: 30963615 Free PMC article.
Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease.
De Chiara F, Thomsen KL, Habtesion A, Jones H, Davies N, Gracia-Sancho J, Manicardi N, Hall A, Andreola F, Paish HL, Reed LH, Watson AA, Leslie J, Oakley F, Rombouts K, Mookerjee RP, Mann J, Jalan R. De Chiara F, et al. Among authors: leslie j. Hepatology. 2020 Mar;71(3):874-892. doi: 10.1002/hep.30890. Epub 2019 Oct 15. Hepatology. 2020. PMID: 31378982
Loss of ELK1 has differential effects on age-dependent organ fibrosis.
Cairns JT, Habgood A, Edwards-Pritchard RC, Joseph C, John AE, Wilkinson C, Stewart ID, Leslie J, Blaxall BC, Susztak K, Alberti S, Nordheim A, Oakley F, Jenkins G, Tatler AL. Cairns JT, et al. Among authors: leslie j. Int J Biochem Cell Biol. 2020 Mar;120:105668. doi: 10.1016/j.biocel.2019.105668. Epub 2019 Dec 23. Int J Biochem Cell Biol. 2020. PMID: 31877385 Free PMC article.
FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis.
Leslie J, Millar BJ, Del Carpio Pons A, Burgoyne RA, Frost JD, Barksby BS, Luli S, Scott J, Simpson AJ, Gauldie J, Murray LA, Finch DK, Carruthers AM, Ferguson J, Sleeman MA, Rider D, Howarth R, Fox C, Oakley F, Fisher AJ, Mann DA, Borthwick LA. Leslie J, et al. JCI Insight. 2020 Feb 27;5(4):e125937. doi: 10.1172/jci.insight.125937. JCI Insight. 2020. PMID: 32102985 Free PMC article.
598 results