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Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability.
Chetty M, Rose RH, Abduljalil K, Patel N, Lu G, Cain T, Jamei M, Rostami-Hodjegan A. Chetty M, et al. Among authors: rose rh. Front Pharmacol. 2014 Nov 26;5:258. doi: 10.3389/fphar.2014.00258. eCollection 2014. Front Pharmacol. 2014. PMID: 25505415 Free PMC article.
A Tutorial on Pharmacodynamic Scripting Facility in Simcyp.
Abduljalil K, Edwards D, Barnett A, Rose RH, Cain T, Jamei M. Abduljalil K, et al. Among authors: rose rh. CPT Pharmacometrics Syst Pharmacol. 2016 Sep;5(9):455-65. doi: 10.1002/psp4.12102. Epub 2016 Aug 29. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27393710 Free PMC article. No abstract available.
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