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Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives.
Kusumi K, Shinozaki K, Yamaura Y, Hashimoto A, Kurata H, Naganawa A, Otsuki K, Matsushita T, Sekiguchi T, Kakuuchi A, Yamamoto H, Seko T. Kusumi K, et al. Among authors: matsushita t. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1209-13. doi: 10.1016/j.bmcl.2016.01.031. Epub 2016 Jan 12. Bioorg Med Chem Lett. 2016. PMID: 26794040
Design, synthesis, and biological evaluation of novel somatostatin receptor subtype-2 agonists: Optimization for potency and risk mitigation of hERG and phospholipidosis.
Ishida A, Okabe Y, Matsushita T, Sekiguchi T, Nishio T, Komagata T, Iwaki M, Miyata H, Katagi J, Naganawa A, Maruyama T, Imagawa A. Ishida A, et al. Among authors: matsushita t. Bioorg Med Chem. 2021 Nov 1;49:116424. doi: 10.1016/j.bmc.2021.116424. Epub 2021 Sep 25. Bioorg Med Chem. 2021. PMID: 34626901
Discovery and SAR Studies of Orally Active Somatostatin Receptor Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly.
Ishida A, Tajima Y, Okabe Y, Matsushita T, Sekiguchi T, Imaide S, Nomura Y, Tanaka M, Nojima S, Yoshida A, Iyoda Y, Aoki S, Nishio T, Komagata T, Iwaki M, Shono T, Naganawa A, Imagawa A. Ishida A, et al. Among authors: matsushita t. ACS Chem Neurosci. 2020 May 20;11(10):1482-1494. doi: 10.1021/acschemneuro.0c00124. Epub 2020 May 1. ACS Chem Neurosci. 2020. PMID: 32315148
Pyrrolo[1,2-b]pyridazines, pyrrolo[2,1-f]triazin-4(3H)-ones, and related compounds as novel corticotropin-releasing factor 1 (CRF₁) receptor antagonists.
Saito T, Obitsu T, Kohno H, Sugimoto I, Matsushita T, Nishiyama T, Hirota T, Takeda H, Matsumura N, Ueno S, Kishi A, Kagamiishi Y, Nakai H, Takaoka Y. Saito T, et al. Among authors: matsushita t. Bioorg Med Chem. 2012 Jan 15;20(2):1122-38. doi: 10.1016/j.bmc.2011.11.015. Epub 2011 Dec 3. Bioorg Med Chem. 2012. PMID: 22196514
Improvement in gait velocity variability after cerebrospinal fluid elimination and its relationship to clinical symptoms in patients with idiopathic normal pressure hydrocephalus.
Yamamoto T, Fujito R, Chadani Y, Kashibayashi T, Kamimura N, Tsuda A, Akamatsu M, Matsushita T, Yamagami T, Ueba T, Saito M, Inoue K, Izumi M, Kazui H. Yamamoto T, et al. Among authors: matsushita t. Geriatr Gerontol Int. 2024 May 29. doi: 10.1111/ggi.14915. Online ahead of print. Geriatr Gerontol Int. 2024. PMID: 38810991
2,213 results